The periosteal microcirculation in health and disease: An update on clinical significance

Andrea Szabó, Ágnes Janovszky, Levente Pócs, M. Borós

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma–orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism. Nevertheless, the axial bones, and in particular the jawbones, and the appendicular bones display differences not only in their blood supply and fracture healing characteristics, but also in respect of the development of osteoporosis and their reactions to treatment modalities (i.e. bisphosphonates). These reactions may also be linked to the differences in periosteal microcirculatory reactions. The present overview summarizes the relevant data of microcirculatory studies focusing on the periosteal reactions in different anatomical locations together with the optimal background methodologies, study models and the most significant observations.

Original languageEnglish
Pages (from-to)5-13
Number of pages9
JournalMicrovascular Research
Volume110
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

Microcirculation
Periosteum
Bone
Health
Bone and Bones
Bone Regeneration
Fracture Healing
Bone Remodeling
Bone Fractures
Diphosphonates
Osteoporosis
Cell Differentiation
Tooth
Repair
Stem Cells
Hormones
Reconstruction (structural)
Wounds and Injuries
Stem cells
Metabolism

Keywords

  • Inflammation
  • Intravital videomicroscopy
  • Ischemia–reperfusion
  • Osteonecrosis
  • Osteoporosis
  • Periosteal microcirculation

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

The periosteal microcirculation in health and disease : An update on clinical significance. / Szabó, Andrea; Janovszky, Ágnes; Pócs, Levente; Borós, M.

In: Microvascular Research, Vol. 110, 01.03.2017, p. 5-13.

Research output: Contribution to journalReview article

Szabó, Andrea ; Janovszky, Ágnes ; Pócs, Levente ; Borós, M. / The periosteal microcirculation in health and disease : An update on clinical significance. In: Microvascular Research. 2017 ; Vol. 110. pp. 5-13.
@article{fe47f724a7544c8d9ad5f0645ef0efee,
title = "The periosteal microcirculation in health and disease: An update on clinical significance",
abstract = "Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma–orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism. Nevertheless, the axial bones, and in particular the jawbones, and the appendicular bones display differences not only in their blood supply and fracture healing characteristics, but also in respect of the development of osteoporosis and their reactions to treatment modalities (i.e. bisphosphonates). These reactions may also be linked to the differences in periosteal microcirculatory reactions. The present overview summarizes the relevant data of microcirculatory studies focusing on the periosteal reactions in different anatomical locations together with the optimal background methodologies, study models and the most significant observations.",
keywords = "Inflammation, Intravital videomicroscopy, Ischemia–reperfusion, Osteonecrosis, Osteoporosis, Periosteal microcirculation",
author = "Andrea Szab{\'o} and {\'A}gnes Janovszky and Levente P{\'o}cs and M. Bor{\'o}s",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.mvr.2016.11.005",
language = "English",
volume = "110",
pages = "5--13",
journal = "Microvascular Research",
issn = "0026-2862",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - The periosteal microcirculation in health and disease

T2 - An update on clinical significance

AU - Szabó, Andrea

AU - Janovszky, Ágnes

AU - Pócs, Levente

AU - Borós, M.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma–orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism. Nevertheless, the axial bones, and in particular the jawbones, and the appendicular bones display differences not only in their blood supply and fracture healing characteristics, but also in respect of the development of osteoporosis and their reactions to treatment modalities (i.e. bisphosphonates). These reactions may also be linked to the differences in periosteal microcirculatory reactions. The present overview summarizes the relevant data of microcirculatory studies focusing on the periosteal reactions in different anatomical locations together with the optimal background methodologies, study models and the most significant observations.

AB - Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma–orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism. Nevertheless, the axial bones, and in particular the jawbones, and the appendicular bones display differences not only in their blood supply and fracture healing characteristics, but also in respect of the development of osteoporosis and their reactions to treatment modalities (i.e. bisphosphonates). These reactions may also be linked to the differences in periosteal microcirculatory reactions. The present overview summarizes the relevant data of microcirculatory studies focusing on the periosteal reactions in different anatomical locations together with the optimal background methodologies, study models and the most significant observations.

KW - Inflammation

KW - Intravital videomicroscopy

KW - Ischemia–reperfusion

KW - Osteonecrosis

KW - Osteoporosis

KW - Periosteal microcirculation

UR - http://www.scopus.com/inward/record.url?scp=84998980242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84998980242&partnerID=8YFLogxK

U2 - 10.1016/j.mvr.2016.11.005

DO - 10.1016/j.mvr.2016.11.005

M3 - Review article

C2 - 27889558

AN - SCOPUS:84998980242

VL - 110

SP - 5

EP - 13

JO - Microvascular Research

JF - Microvascular Research

SN - 0026-2862

ER -