The pattern of a T(H)1 cytokine in autoimmune thyroiditis

Doina Drugarin, Serban Negru, Andrea Koreck, Ioana Zosin, Corina Cristea

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58 Citations (Scopus)

Abstract

This study performed on 51 patients with autoimmune thyroiditis and 15 healthy subjects was aimed at correlating the activation of T cells and the secretion of inflammatory cytokine with echography and thyroid functional assays. A significant increase of activated T cells was observed in Hashimoto patients illustrated by an increased percentage of CD3 + CD25 + T cells (P<0.01). Similarly, increased amounts of IL-2, TNF-α and IFN-γ were in the serum of patients compared with the control group in which these cytokines are barely detectable. An in vitro study shows a significant increase of IL-2 and TNF-α upon the exposure to Concanavalin A. These results suggest that T(H)1 secreting inflammatory cytokines may contribute to pathogenesis of autoimmune thyroiditis. (C) 2000 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalImmunology letters
Volume71
Issue number2
DOIs
Publication statusPublished - Feb 1 2000

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Keywords

  • Autoimmune thyroiditis
  • Immunophenotyping
  • T(H)1 cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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