The pathomorphological diagnosis of acute leukaemias: cytology, cytochemistry and immunocytology.

G. Kelényi, V. Kalász, A. Matolcsy

Research output: Contribution to journalArticle

Abstract

In 74 cases of acute leukaemia and of the blastic phase of chronic granulocytic leukaemia (CML), monoclonal antibodies of the "VI" series and a few commercially available antibodies proved to be of valuable help in establishing a definite diagnosis. In 4 out of 35 cases of AML (FAB-M 1-5), and in 2 out of 16 of the blastic phase of CML only the use of monoclonal antibodies secured the diagnosis. In the group of acute lymphoid leukaemias subtypes corresponding to various levels of differentiation, were defined. The blasts of 3 patients out of the 74 did not express any of the markers studied. Two additional cases were investigated for platelet peroxidase and studied with the antiplatelet antibodies VIPL 1, 2 and 3 by the electron microscope. These cases proved to be acute megakaryoblastic leukaemias (acute myelofibrosis).

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalFolia haematologica : internationales Magazin fur klinische und morphologische Blutforschung
Volume116
Issue number1
Publication statusPublished - 1989

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Histocytochemistry
Cell Biology
Leukemia
Leukemia, Megakaryoblastic, Acute
Monoclonal Antibodies
Primary Myelofibrosis
Antibodies
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Peroxidase
Blood Platelets
Electrons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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