The papain susceptibility of IgG myeloma proteins of different heavy chain subclasses

J. Gergely, H. H. Fudenberg, Erna Van Loghem

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43 Citations (Scopus)

Abstract

Papain-susceptibility of 50 IgG myeloma proteins was investigated. 34 per cent of the proteins proved to be papain-resistant. A definite correlation between papain-susceptibility and heavy chain subclass was found in the cases of myeloma proteins belonging to subclasses IgG2, IgG3, and IgG4, as the IgG2 and IgG4 proteins were papain-resistant, whereas the IgG3 proteins were papain-sensitive. There exists, however, a heterogeneity in the subclass IgGl.

Original languageEnglish
Pages (from-to)1-4,IN1-IN2,5-6
JournalImmunochemistry
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 1970

ASJC Scopus subject areas

  • Medicine(all)

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