A p53 gén és fehérje 2005-ben: Új eredmények, ígéretes lehetoségek

Translated title of the contribution: The p53 gene and protein in 2005: New results, promising opportunities

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The p53 gene is one of the most important genes which is involved in the regulation of cell division and tumor formation. The normal function of the p53 protein is to arrest the cell division and to turn the cell towards apoptosis in the case of cell stress and DNA damage, hereby to protect the integrity of the genome. Several p53 gene mutations that have function in carcinogenesis have been found in various tumors, including gastrointestinal carcinomas. The loss of p53 response plays an important role in the malignantly transformed cell proliferation. Promising experiments try to substitute the lost functions of the p53 gene. With their help new anti-tumor therapeutic methods should be developed.

Original languageHungarian
Pages (from-to)1587-1594
Number of pages8
JournalOrvosi Hetilap
Volume146
Issue number30
Publication statusPublished - 2005

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p53 Genes
Cell Division
Neoplasms
Proteins
DNA Damage
Carcinogenesis
Cell Proliferation
Genome
Apoptosis
Carcinoma
Mutation
Genes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A p53 gén és fehérje 2005-ben : Új eredmények, ígéretes lehetoségek. / Szoke, Dominika; Sípos, F.; Spisák, S.; Molnár, B.; Tulassay, Z.

In: Orvosi Hetilap, Vol. 146, No. 30, 2005, p. 1587-1594.

Research output: Contribution to journalArticle

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