The oxidation state of phospholipids controls the oxidative burst in neutrophil granulocytes

Stephan Blüml, Berit Rosc, Akos Lorincz, Maria Seyerl, Stefanie Kirchberger, Olga Oskolkova, Valery N. Bochkov, Otto Majdic, Erzsebet Ligeti, Johannes Stöckl

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The activation of neutrophil granulocytes has to be carefully controlled to balance desired activity against invading pathogens while avoiding overwhelming activation leading to host tissue damage. We now show that phospholipids are potential key players in this process by either enhancing or dampening the production of reactive oxygen species (ROS) during the oxidative burst. Unoxidized phospholipids induce the production of ROS, and they also work synergistically with FMLP in potentiating the oxidative burst in neutrophil granulocytes. Oxidation of these phospholipids, however, turns them into potent inhibitors of the oxidative burst. OxPls specifically inhibit ROS production by inhibiting the assembly of the phagocyte oxidase complex but do not alter neutrophil viability, nor do they interfere with MAPK activation. Furthermore, up-regulation of the activation marker Mac-1 and phagocytosis of bacteria is not affected. Therefore, phospholipids may act as sensors of oxidative stress in tissues and either positively or negatively regulate neutrophil ROS production according to their oxidation state.

Original languageEnglish
Pages (from-to)4347-4353
Number of pages7
JournalJournal of Immunology
Volume181
Issue number6
DOIs
Publication statusPublished - Sep 15 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Blüml, S., Rosc, B., Lorincz, A., Seyerl, M., Kirchberger, S., Oskolkova, O., Bochkov, V. N., Majdic, O., Ligeti, E., & Stöckl, J. (2008). The oxidation state of phospholipids controls the oxidative burst in neutrophil granulocytes. Journal of Immunology, 181(6), 4347-4353. https://doi.org/10.4049/jimmunol.181.6.4347