The outcome of status epilepticus and long-term follow-up

László Horváth, István Fekete, Márk Molnár, Réka Válóczy, Sándor Márton, Klára Fekete

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Objective: This study was to investigate the outcome of status epilepticus (SE) associated with antiepileptic therapy during SE and in follow-up period, risk factors including age, co-morbidities, pre-existing epilepsy, and etiology in the East-Hungarian region. Methods: A prospective cross-sectional database was compiled from outpatient files between 2013 and 2017. Follow-up ended on 30.06.2018. Results: One hundred and thirty five episodes (male: 68, 50.4%) were evaluated, mean age and follow-up time being 64.1 ± 13.9 years and 39.9 ± 14.2 months, respectively. Of the 89 patients with pre-existing epilepsy, 34 failed to visit the outpatient unit regularly. Case fatality rate was 25.2% and 31 patients (30.7%) died after discharge due to comorbidities; their mean survival time was 10.44 ± 8 months. Focal, generalized and combined type epilepsies were diagnosed in 67 patients (49.6%), 47 patients (34.8%), and 21 patients (15.6%) of SE, respectively. Nine patients had non-convulsive SE (NCSE). Mean seizure-free period was 6.8 ± 6.9 months. Patients taking carbamazepine (20.9%; OR: 0.37, 95%CI: 0.16–0.82; p = 0.018), levetiracetam (27.5%; OR: 0.51, 95%CI: 0.27–0.97; p = 0.041), or valproate (11.1%; OR: 0.18, 95%CI: 0.05–0.61; p = 0.0043) were expected to achieve seizure freedom after SE. The worst outcome was linked to advanced age, etiology, new onset status epilepticus, NCSE, and focal status epilepsy. Conclusion: This study highlights the importance of regular care and patient follow-up.

Original languageEnglish
Article number427
JournalFrontiers in Neurology
Issue numberAPR
Publication statusPublished - 2019


  • Antiepileptic drug treatment
  • Follow-up
  • Outcome
  • Risk factors
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Horváth, L., Fekete, I., Molnár, M., Válóczy, R., Márton, S., & Fekete, K. (2019). The outcome of status epilepticus and long-term follow-up. Frontiers in Neurology, 10(APR), [427].