The organ distribution of liposome-encapsulated and free cobalt in rats. Liposomes decrease the cardiac uptake of the metal

J. Szebeni, Ray Garcia, Cleamond D. Eskelson, Milos Chvapil

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40 % of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. These vesicles also tended to decrease the uptake of cobalt in the kidney and the carcass, and to increase it in the spleen and the bones. Liposomes prepared from soybean phosphatidylcholine (SPC)/CH (1:1) had no effect on the uptake of cobalt in the heart, whereas increased its level in the spleen, liver and lung. The time-course of cobalt deposition in the organs displayed substantial variation with the different preparations. Most importantly, no buildup of cobalt level was observed in the heart when the metal was administered in SM/CH vesicles. While conforming known effects of liposomes on the organ-distribution of entrapped drugs, our findings suggest that administration of cobalt in SM/CH liposome-encapsulated form may result in decreased cardiotoxicity and thus increased safety of cobalt-treatment in some anemias.

Original languageEnglish
Pages (from-to)729-736
Number of pages8
JournalLife Sciences
Volume45
Issue number8
DOIs
Publication statusPublished - 1989

Fingerprint

Cobalt
Liposomes
Rats
Metals
Sphingomyelins
Cholesterol
Spleen
Phosphatidylcholines
Soybeans
Liver
Anemia
Bone
Kidney
Safety
Bone and Bones
Lung
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

The organ distribution of liposome-encapsulated and free cobalt in rats. Liposomes decrease the cardiac uptake of the metal. / Szebeni, J.; Garcia, Ray; Eskelson, Cleamond D.; Chvapil, Milos.

In: Life Sciences, Vol. 45, No. 8, 1989, p. 729-736.

Research output: Contribution to journalArticle

Szebeni, J. ; Garcia, Ray ; Eskelson, Cleamond D. ; Chvapil, Milos. / The organ distribution of liposome-encapsulated and free cobalt in rats. Liposomes decrease the cardiac uptake of the metal. In: Life Sciences. 1989 ; Vol. 45, No. 8. pp. 729-736.
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