The olfactory system in Alzheimer's disease: Pathology, pathophysiology and pathway for therapy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Olfaction is frequently mentioned as a "neglected sense", although the olfactory system has several interesting and unique anatomical and physiological features. Olfactory involvement is present in several degenerative disorders, especially in Alzheimer's disease (AD). The peripheral and central parts of the olfactory system are damaged even in the early stages of AD, manifesting in profound olfactory deficits. Besides the early pathology, the olfactory system may be involved in the pathogenesis of AD by providing a route of entry for pathological agents still unknown. In contrast to this olfactory vector hypothesis, the olfactory system can be used to deliver therapeutic agents in AD, such as nerve growth factor and insulin, by decreasing the side-effects of the therapy or providing a non-invasive method of delivery.

Original languageEnglish
Pages (from-to)34-45
Number of pages12
JournalTranslational Neuroscience
Volume4
Issue number1
DOIs
Publication statusPublished - Mar 2013

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Alzheimer Disease
Pathology
Smell
Nerve Growth Factor
Therapeutics
Insulin

Keywords

  • Alzheimer's disease
  • Limbic system
  • Neurofibrillary tangles
  • Olfaction
  • Olfactory vector hypothesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The olfactory system in Alzheimer's disease : Pathology, pathophysiology and pathway for therapy. / Kovács, T.

In: Translational Neuroscience, Vol. 4, No. 1, 03.2013, p. 34-45.

Research output: Contribution to journalArticle

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