The nucleophilic substitution reaction for [18F]fluoride-ion on the series of N6-benzoyl-2′,3′-isopropylideneadenosine-5′- sulfonates

S. Lehel, G. Horváth, I. Boros, T. Márián, L. Trón

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Abstract

The reaction of the nca [18F]fluoride ion was investigated toward a series of N6-benzoyl 2′,3′-isopropylidene-adenosine-5′-sulfonates including the methane-(mesylate), p-toluene-(tosylate), p-nitro-benzene-(nosylate)- and 2,2,2-trifluoro-ethane-sulfonate (tresylate) derivatives under usual nucleophilic substitution conditions. In these reactions cyclisation of the title compounds was observed whilst the radiofluorination took place only with low yield. The fluorine-18 uptake was found to be 1.17% for mesylate, 1.46% for tosylate, 0.99% for nosylate and 0.40% for tresylate under the conditions applied.

Original languageEnglish
Article number400108
Pages (from-to)413-416
Number of pages4
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume251
Issue number3
DOIs
Publication statusPublished - Jan 1 2002

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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