The Nucleolar Organizer Regions in Hyperplastic and Tumorous Lesions of the Human Liver

A. Zalatnai, K. Lapis, I. Fehér

Research output: Contribution to journalArticle

10 Citations (Scopus)


The alterations of the argyrophil nucleolar organizer regions (AgNORs) have been studied in hyperplastic and neoplastic human liver lesions. The material studied included: 11 focal nodular hyperplasias (FNH), 3 adenomas, 19 hepatocellular carcinomas (HCC), 2 hepatoblastomas, 8 liver metastases. In 5 cases tumor-free (normal) liver was also available for study. The mean AgNOR numbers were significantly increased in all of these lesions (in FNHs 3.36 ± 1.43, in the adenomas 2.48 ± 1.293 in the HCCs 3.32 ± 1.43, in the hepatoblastomas 3.33 ± 1.33 and in the metastases 4.86 ± 1.54) compared to those observed in normal liver (0.86 ± 0.85). The highly increased AgNOR number in FNHs was particularly surprising and it seemed to us that based on AgNOR numbers the FNHs could be divided into two groups. With the exception of hepatoblastomas in all primary liver lesions the AgNOR counts distributed on a rather broad scale resulting in overlapping in hyperplastic and tumorous cases. The authors concluded that the AgNOR counts reflect only the proliferative activity of a given cell population and at least in the liver they cannot serve as basis for distinction between the hyperplastic, benign and malignant neoplastic lesions.

Original languageEnglish
Pages (from-to)536-541
Number of pages6
JournalPathology Research and Practice
Issue number5
Publication statusPublished - Jan 1 1993


  • AgNOR technique
  • Focal nodular hyperplasia
  • Hyperplastic lesions
  • Liver tumours
  • Nucleolar organizer regions

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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