The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors

Antoine Guichet, John W.R. Copeland, Miklós Erdélyi, Daniela Hlousek, Péter Závorszky, Jacqueline Ho, Susan Brown, Anthony Percival-Smith, Henry M. Krause, Anne Ephrussi

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153 Citations (Scopus)

Abstract

Nuclear hormone receptors and homeodomain proteins are two classes of transcription factor that regulate major developmental processes. Both depend on interactions with other proteins for specificity and activity. The Drosophila gene fushi tarazu (ftz), which encodes a homeodomain protein (Ftz), is required zygotically for the formation of alternate segments in the developing embryo. Here we show that the orphan nuclear receptor αFtz-F1 (ref. 3), which is deposited in the egg during oogenesis, is an obligatory cofactor for Ftz. The two proteins interact specifically and directly, both in vitro and in vivo, through a conserved domain in the Ftz polypeptide. This interaction suggests that other nuclear receptor/homeodomain protein interactions may be important and common in developing organisms.

Original languageEnglish
Pages (from-to)548-552
Number of pages5
JournalNature
Volume385
Issue number6616
DOIs
Publication statusPublished - Feb 6 1997

ASJC Scopus subject areas

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    Guichet, A., Copeland, J. W. R., Erdélyi, M., Hlousek, D., Závorszky, P., Ho, J., Brown, S., Percival-Smith, A., Krause, H. M., & Ephrussi, A. (1997). The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors. Nature, 385(6616), 548-552. https://doi.org/10.1038/385548a0