The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes

Péter Csermely, Lajos Radics, Carlo Rossi, Márta Szamel, Maurizio Ricci, Katalin Mihály, János Somogyi

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Abstract

Earlier studies have disclosed that leucinostatin A, a hydrophobic nonapeptide antibiotic, assumes an α-helical secondary structure in nonpolar environments. The present report demonstrates that the peptide acts as a weak ionophore facilitating the transport of mono-and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes. Leucinostatin A does not change the thymidine uptake of both resting mouse thymocytes and peripheral blood lymphocytes but dose-dependently prevents the activation of T lymphocytes by tetradecanoyl-phorbol-acetate and by anti-T cell receptor antibody.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalBBA - Molecular Cell Research
Volume1221
Issue number2
DOIs
Publication statusPublished - Mar 31 1994

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Keywords

  • Antibiotic
  • Cyclosporin A
  • Immunosuppression
  • Ionophore
  • Leucinostatin A
  • T lymphocyte

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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