The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes

P. Csermely, Lajos Radics, Carlo Rossi, Márta Szamel, Maurizio Ricci, Katalin Mihály, János Somogyi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Earlier studies have disclosed that leucinostatin A, a hydrophobic nonapeptide antibiotic, assumes an α-helical secondary structure in nonpolar environments. The present report demonstrates that the peptide acts as a weak ionophore facilitating the transport of mono-and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes. Leucinostatin A does not change the thymidine uptake of both resting mouse thymocytes and peripheral blood lymphocytes but dose-dependently prevents the activation of T lymphocytes by tetradecanoyl-phorbol-acetate and by anti-T cell receptor antibody.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1221
Issue number2
DOIs
Publication statusPublished - Mar 31 1994

Fingerprint

leucinostatin A
Ionophores
Immunosuppressive Agents
Artificial Membranes
T-Lymphocytes
Divalent Cations
Thymocytes
T-Cell Antigen Receptor
Thymidine
Acetates
Cell Membrane
Lymphocytes
Anti-Bacterial Agents
Peptides
Antibodies

Keywords

  • Antibiotic
  • Cyclosporin A
  • Immunosuppression
  • Ionophore
  • Leucinostatin A
  • T lymphocyte

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. / Csermely, P.; Radics, Lajos; Rossi, Carlo; Szamel, Márta; Ricci, Maurizio; Mihály, Katalin; Somogyi, János.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1221, No. 2, 31.03.1994, p. 125-132.

Research output: Contribution to journalArticle

Csermely, P. ; Radics, Lajos ; Rossi, Carlo ; Szamel, Márta ; Ricci, Maurizio ; Mihály, Katalin ; Somogyi, János. / The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. In: Biochimica et Biophysica Acta - Molecular Cell Research. 1994 ; Vol. 1221, No. 2. pp. 125-132.
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