The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease.

Antonio Currais, Tibor Hortobágyi, Salvador Soriano

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division. Nevertheless, expression of cell cycle modulators persists after neuronal differentiation and is upregulated under stress conditions, such as trophic factor deprivation, oxidative stress and the presence of DNA damaging agents. This apparent reactivation of the cell cycle has been postulated as a sine qua non for neuronal death in response to those stress conditions, particularly in Alzheimer's disease. However, the physiological and pathogenic implications of a putative neuronal cell cycle are far from clear. Here, we discuss the notion of the neuronal cell cycle as a mediator of cell death, with particular emphasis on Alzheimer's disease.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalAging
Volume1
Issue number4
DOIs
Publication statusPublished - Apr 2009

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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