The neurobiology of neurooncology

Tracy Ann Read, Balazs Hegedus, Robert Wechsler-Reya, David H. Gutmann

Research output: Contribution to journalReview article

42 Citations (Scopus)


The histological classification of brain tumors currently is based on the morphological appearance and protein expression patterns that reflect specific cell types within the central nervous system. Recent studies have suggested that the cells of origin for brain tumors may persist in the fully formed tumors, and that these "cancer stem cells" might represent the relevant cellular targets for anticancer therapy. In this regard, insights into the developmental neurobiology of brain tumors has significant impact on our understanding of the molecular and cellular pathogenesis of these devastating cancers, as well as the development of new strategies for treating brain tumors.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalAnnals of Neurology
Issue number1
Publication statusPublished - Jul 1 2006

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Read, T. A., Hegedus, B., Wechsler-Reya, R., & Gutmann, D. H. (2006). The neurobiology of neurooncology. Annals of Neurology, 60(1), 3-11.