The neonatal Fc receptor plays a crucial role in the metabolism of IgG in livestock animals

Judit Cervenak, Imre Kacskovics

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

The role of the FcRn is fundamental in IgG metabolism. It is involved in transporting maternal immunity and protects IgG from fast degradation throughout life. While the acquisition of the humoral immunity through the transfer of IgG from mother to offspring shows species-specific differences, the mechanism how FcRn protects IgG from degradation is highly similar in all species analyzed so far. This review summarizes the current understanding of the FcRn-mediated IgG metabolism in livestock animals (cattle, sheep and pig) and point out those aspects that remain to be exposed for better understanding the function of this system in these species and also to take advantages of it for economical purposes.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalVeterinary Immunology and Immunopathology
Volume128
Issue number1-3
DOIs
Publication statusPublished - Mar 15 2009

Keywords

  • IgG metabolism
  • Maternal immune transport
  • Neonatal Fc receptor

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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