The neglected terminators: Rho family GAPs in neutrophils

Roland Csépányi-Kömi, Máté Pásztor, Balázs Bartos, E. Ligeti

Research output: Contribution to journalArticle

Abstract

Background: GTPase-activating proteins (GAPs) accelerate the rate of hydrolysis of GTP bound to small GTPases, thereby limiting the prevalence and concentration of the active, GTP-bound form of these proteins. The large number of potential GAPs acting on members of the Rho family of small GTPases raises the question of specificity or redundancy. Results: In this review, we summarize experimental data obtained on the role of Rho family GAPs in neutrophils, highlight cases where more than one GAP is involved in a physiological function and show examples that GAPs can be involved not only in termination but also in initiation of cellular processes. We demonstrate that the expression-level regulation of GAPs may also occur in short-living cells such as neutrophils. Finally, we provide insight into the existence and structure of molecular complexes in which Rho family GAPs are involved. Conclusion: GAPs play more complex and varied roles than being simple terminators of cellular processes.

Original languageEnglish
JournalEuropean Journal of Clinical Investigation
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • GTPase activating proteins
  • neutrophils
  • Rho-family small GTPases

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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