The Nck family of adapter proteins: Regulators of actin cytoskeleton

Research output: Contribution to journalReview article

171 Citations (Scopus)


SH2/SH3 domain-containing adapter proteins, such as the Nck family, play a major role in regulating tyrosine kinase signalling. They serve to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates. Initially, it was not clear why cells from nematodes to vertebrates contain redundant and closely related SH2/SH3 adapters, such as Grb2, Crk and Nck. Recent evidence suggests that their biological roles are clearly different, whereas, for example, Grb2 connects activated receptor tyrosine kinases to Sos and Ras, leading to cell proliferation. The proteins of Nck family are implicated in organisation of actin cytoskeleton, cell movement or axon guidance in flies. In this review, the author attempts to summarise signalling pathways in which Nck plays a critical role.

Original languageEnglish
Pages (from-to)723-731
Number of pages9
JournalCellular Signalling
Issue number9
Publication statusPublished - Jun 17 2002



  • Actin cytoskeleton
  • Nck
  • Rho proteins
  • SH2/SH3 domains

ASJC Scopus subject areas

  • Cell Biology

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