The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents

Julien Rousseaux, Alain Duhamel, Julie Dumont, Jean Dallongeville, Denes Molnar, Kurt Widhalm, Yannis Manios, Michael Sjöström, Anthony Kafatos, Christina Breidenassel, Marcela Gonzales-Gross, Magdalena Cuenca-Garcia, Laura Censi, Marcos Ascensión, Stefaan De Henauw, Luis A. Moreno, Aline Meirhaeghe, Frédéric Gottrand

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dietary n-3 long-chain PUFAs (LC-PUFAs) are associated with improvement in the parameters of the metabolic syndrome (MetS). Glucokinase regulatory protein (GCKR) is a key protein regulating intracellular glucose disposal. Our aim was to investigate: i ) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphism and parameters of the MetS; and ii ) a potential influence of n-3 and n-6 LC-PUFA levels on this relationship in the HELENA study (1,155 European adolescents). Linear regression analyses were performed to study the association between rs1260326 and the outcomes of interest. Interactions between rs1260326 and LC-PUFA levels on outcomes were explored. The T allele of rs1260326 was associated with higher serum TG concentrations compared with the C allele. In contrast to n-6 LC-PUFA levels, a significant interaction ( P = 0.01) between rs1260326 and total n-3 LC-PUFA levels on serum TG concentrations was observed. After stratification on the n-3 LC-PUFA median values, the association between rs1260326 and TG concentration was significant only in the group with high n-3 LC-PUFA levels. In conclusion, this is the first evidence that n-3 LC-PUFAs may modulate the impact of the GCKR rs1260326 polymorphism on TG concentrations in adolescents. Several molecular mechanisms, in link with glucose uptake, could explain these findings.

Original languageEnglish
Pages (from-to)1774-1780
Number of pages7
JournalJournal of Lipid Research
Volume56
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Glucokinase regulatory protein
  • Lipid metabolism
  • Polyunsaturated fatty acid

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

Fingerprint Dive into the research topics of 'The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents'. Together they form a unique fingerprint.

  • Cite this

    Rousseaux, J., Duhamel, A., Dumont, J., Dallongeville, J., Molnar, D., Widhalm, K., Manios, Y., Sjöström, M., Kafatos, A., Breidenassel, C., Gonzales-Gross, M., Cuenca-Garcia, M., Censi, L., Ascensión, M., De Henauw, S., Moreno, L. A., Meirhaeghe, A., & Gottrand, F. (2015). The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents. Journal of Lipid Research, 56(9), 1774-1780. https://doi.org/10.1194/jlr.M057570