TY - JOUR
T1 - The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents
AU - Rousseaux, Julien
AU - Duhamel, Alain
AU - Dumont, Julie
AU - Dallongeville, Jean
AU - Molnar, Denes
AU - Widhalm, Kurt
AU - Manios, Yannis
AU - Sjöström, Michael
AU - Kafatos, Anthony
AU - Breidenassel, Christina
AU - Gonzales-Gross, Marcela
AU - Cuenca-Garcia, Magdalena
AU - Censi, Laura
AU - Ascensión, Marcos
AU - De Henauw, Stefaan
AU - Moreno, Luis A.
AU - Meirhaeghe, Aline
AU - Gottrand, Frédéric
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Dietary n-3 long-chain PUFAs (LC-PUFAs) are associated with improvement in the parameters of the metabolic syndrome (MetS). Glucokinase regulatory protein (GCKR) is a key protein regulating intracellular glucose disposal. Our aim was to investigate: i ) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphism and parameters of the MetS; and ii ) a potential influence of n-3 and n-6 LC-PUFA levels on this relationship in the HELENA study (1,155 European adolescents). Linear regression analyses were performed to study the association between rs1260326 and the outcomes of interest. Interactions between rs1260326 and LC-PUFA levels on outcomes were explored. The T allele of rs1260326 was associated with higher serum TG concentrations compared with the C allele. In contrast to n-6 LC-PUFA levels, a significant interaction ( P = 0.01) between rs1260326 and total n-3 LC-PUFA levels on serum TG concentrations was observed. After stratification on the n-3 LC-PUFA median values, the association between rs1260326 and TG concentration was significant only in the group with high n-3 LC-PUFA levels. In conclusion, this is the first evidence that n-3 LC-PUFAs may modulate the impact of the GCKR rs1260326 polymorphism on TG concentrations in adolescents. Several molecular mechanisms, in link with glucose uptake, could explain these findings.
AB - Dietary n-3 long-chain PUFAs (LC-PUFAs) are associated with improvement in the parameters of the metabolic syndrome (MetS). Glucokinase regulatory protein (GCKR) is a key protein regulating intracellular glucose disposal. Our aim was to investigate: i ) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphism and parameters of the MetS; and ii ) a potential influence of n-3 and n-6 LC-PUFA levels on this relationship in the HELENA study (1,155 European adolescents). Linear regression analyses were performed to study the association between rs1260326 and the outcomes of interest. Interactions between rs1260326 and LC-PUFA levels on outcomes were explored. The T allele of rs1260326 was associated with higher serum TG concentrations compared with the C allele. In contrast to n-6 LC-PUFA levels, a significant interaction ( P = 0.01) between rs1260326 and total n-3 LC-PUFA levels on serum TG concentrations was observed. After stratification on the n-3 LC-PUFA median values, the association between rs1260326 and TG concentration was significant only in the group with high n-3 LC-PUFA levels. In conclusion, this is the first evidence that n-3 LC-PUFAs may modulate the impact of the GCKR rs1260326 polymorphism on TG concentrations in adolescents. Several molecular mechanisms, in link with glucose uptake, could explain these findings.
KW - Glucokinase regulatory protein
KW - Lipid metabolism
KW - Polyunsaturated fatty acid
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U2 - 10.1194/jlr.M057570
DO - 10.1194/jlr.M057570
M3 - Article
C2 - 26136510
AN - SCOPUS:84940983772
VL - 56
SP - 1774
EP - 1780
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 9
ER -