The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling

G. Sármay, Adrienn Angyal, Ákos Kertész, Máté Maus, Dávid Medgyesi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The Grb2 associated binder (Gab) adaptor/scaffolding protein family comprises conserved proteins: mammalian Gab1, Gab2 and Gab3, Drosophila Dos and Caenorhabditis elegans Soc1. Gab adaptors are involved in multiple signaling pathways mediated by receptor- and non-receptor protein tyrosine kinases (PTKs), and become phosphorylated upon stimulation by growth factors-, cytokines-, Ig Fc- and antigen receptors. Through its phosphorylated tyrosine containing motifs, proline-rich sequences and pleckstrin homologue (PH) domain Gab adaptors may generate an interacting platform for proteins with SH2 and SH3 domains and may transfer these molecules to the plasma membrane, thereby contributing to their activation. This review will concentrate on the function of mammalian Gab proteins in the signal transduction triggered by immune receptors.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalImmunology Letters
Volume104
Issue number1-2
DOIs
Publication statusPublished - Apr 15 2006

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src Homology Domains
Proteins
Antigen Receptors
Fc Receptors
Caenorhabditis elegans
Sequence Homology
Proline
Protein-Tyrosine Kinases
Drosophila
Tyrosine
Signal Transduction
Intercellular Signaling Peptides and Proteins
Cell Membrane
Cytokines
platelet protein P47

Keywords

  • Adaptor protein
  • Membrane receptors
  • Signaling
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. / Sármay, G.; Angyal, Adrienn; Kertész, Ákos; Maus, Máté; Medgyesi, Dávid.

In: Immunology Letters, Vol. 104, No. 1-2, 15.04.2006, p. 76-82.

Research output: Contribution to journalArticle

Sármay, G. ; Angyal, Adrienn ; Kertész, Ákos ; Maus, Máté ; Medgyesi, Dávid. / The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. In: Immunology Letters. 2006 ; Vol. 104, No. 1-2. pp. 76-82.
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