The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling

Gabriella Sármay, Adrienn Angyal, Ákos Kertész, Máté Maus, Dávid Medgyesi

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The Grb2 associated binder (Gab) adaptor/scaffolding protein family comprises conserved proteins: mammalian Gab1, Gab2 and Gab3, Drosophila Dos and Caenorhabditis elegans Soc1. Gab adaptors are involved in multiple signaling pathways mediated by receptor- and non-receptor protein tyrosine kinases (PTKs), and become phosphorylated upon stimulation by growth factors-, cytokines-, Ig Fc- and antigen receptors. Through its phosphorylated tyrosine containing motifs, proline-rich sequences and pleckstrin homologue (PH) domain Gab adaptors may generate an interacting platform for proteins with SH2 and SH3 domains and may transfer these molecules to the plasma membrane, thereby contributing to their activation. This review will concentrate on the function of mammalian Gab proteins in the signal transduction triggered by immune receptors.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalImmunology letters
Volume104
Issue number1-2
DOIs
Publication statusPublished - Apr 15 2006

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Keywords

  • Adaptor protein
  • Membrane receptors
  • Signaling
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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