The monoamine oxidase inhibitory effect of new homopyrimidazole derivatives

K. Magyar, E. Satory, Z. Meszaros, J. Knoll

Research output: Contribution to journalArticle

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Abstract

The strong monamine oxidase (MAO) inhibitory effects of the homopyrimidazole derivatives 6 methyl 3 [(2 oxo 3 oxazolidinyl) imino methyl] 2 (1 piperidinyl) 4H pyrido (1,2 a) pyrimidine 4 one, (MZ 471) and 6 methyl 3 [(2 oxo 3 oxazolidinyl) imino methyl] 2 (1 piperidinyl) 6,7,8,9 tetrahydro 4H pyrido (1,2 a) pyrimidine 4 one, (MZ 472) on rat brain and liver homogenate are described. Both compounds are ineffective in vitro but they are powerful MAO inhibitors in vivo. The inhibitory potency of the compounds equals that of pargyline and deprenyl. The inhibition of MAO by MZ 471 and MZ 472 is irreversible and 7 days are needed for the complete recovery of the enzyme. MZ 471 and MZ 472 inhibit mainly the oxidative deamination of tyramine; they have less effect on benzylamine metabolism, while their inhibitory potency on serotonin oxidation falls in between.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalMedical Biology
Volume52
Issue number6
Publication statusPublished - 1974

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Monoamine Oxidase
Oxidoreductases
Pargyline
Selegiline
Deamination
Tyramine
Serotonin
Liver
Brain
Enzymes
MZ 472
homopyrimidazoles
pyrimidine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The monoamine oxidase inhibitory effect of new homopyrimidazole derivatives. / Magyar, K.; Satory, E.; Meszaros, Z.; Knoll, J.

In: Medical Biology, Vol. 52, No. 6, 1974, p. 384-389.

Research output: Contribution to journalArticle

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