The modulation of pacing-induced changes in intracellular sodium levels by extracellular Ca2+ in isolated perfused rat hearts

T. Símor, T. Lóránd, Balázs Gaszner, Gabriel A. Elgavish

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study demonstrates the inverse relationship between extracellular free calcium ([Ca(o)](f)) and intracellular sodium ([Na(i)]) in isolated perfused rat hearts and thus supports the role of [Na(i)] in the 'calcium paradox'. It also shows that the extent of the increase in [Na(i)] (Δ[Na(i)]), and the extent of the decrease in left ventricular developed pressure (ΔLVDP) in isolated perfused rat hearts, induced by pacing, is modulated by [Ca(o)](f). At low (0.24 mM) as well as normal (1.15 mM) [Ca(o)](f), [Na(i)] increased with pacing, progressively and significantly (P2+ uptake, and thus SR Ca, in a manner that results in a modulated left ventricular force development.

Original languageEnglish
Pages (from-to)1225-1235
Number of pages11
JournalJournal of Molecular and Cellular Cardiology
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 1997

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Sodium
Calcium
Ventricular Pressure

Keywords

  • Na NMR
  • Cardiac staircase
  • Extracellular calcium
  • Intracellular sodium
  • Pacing
  • Perfused rat heart

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

The modulation of pacing-induced changes in intracellular sodium levels by extracellular Ca2+ in isolated perfused rat hearts. / Símor, T.; Lóránd, T.; Gaszner, Balázs; Elgavish, Gabriel A.

In: Journal of Molecular and Cellular Cardiology, Vol. 29, No. 4, 04.1997, p. 1225-1235.

Research output: Contribution to journalArticle

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