The mode of action of alkaloids

O. Csuka, J. Sugar, I. Sajo

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A good correlation was found between the crystal formation capacity and biological effectiveness of the vinca alkaloids. Crystal formation probably occurs in two steps: (1) disruption of microtubules into soluble tubulin, and (2) irregular polymerization of tubulin into hexagonal crystals. The crystal formation induced by vinca alkaloids was influenced by colchicine, podophylline, SH inhibitors (N ethyl maleimide and thiomerosal) and phosphodiesterase inhibitors (theophylline and dibutyryl cAMP). Colchicine treatment enhanced the number of paracrystals. The SH inhibitors and phosphodiesterase inhibitors decreased the number of alkaloid induced crystals. In addition to the appearance of paracrystals, the alkaloids and alkylating agents induced the formation of numerous microfilaments.

Original languageEnglish
Pages (from-to)350-356
Number of pages7
JournalUnknown Journal
Publication statusPublished - Jan 1 1976

ASJC Scopus subject areas

  • Medicine(all)

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    Csuka, O., Sugar, J., & Sajo, I. (1976). The mode of action of alkaloids. Unknown Journal, No.375, 350-356.