The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease

Erin L. Seifert, E. Ligeti, Johannes A. Mayr, Neal Sondheimer, György Hajnóczky

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The mitochondrial phosphate carrier (PiC) is a mitochondrial solute carrier protein, which is encoded by SLC25A3 in humans. PiC delivers phosphate, a key substrate of oxidative phosphorylation, across the inner mitochondrial membrane. This transport activity is also relevant for allowing effective mitochondrial calcium handling. Furthermore, PiC has also been described to affect cell survival mechanisms via interactions with cyclophilin D and the viral mitochondrial-localized inhibitor of apoptosis (vMIA). The significance of PiC has been supported by the recent discovery of a fatal human condition associated with PiC mutations. Here, we present first the early studies that lead to the discovery and molecular characterization of the PiC, then discuss the very recently developed mouse models for PiC and pathological mutations in the human SLC25A3 gene.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume464
Issue number2
DOIs
Publication statusPublished - Jul 30 2015

Fingerprint

Phosphate Transport Proteins
Mitochondrial Diseases
Metabolism
Carrier Proteins
Genes
Phosphates
Cells
Apoptosis
Calcium
Membranes
Substrates
Mutation
Oxidative Phosphorylation
Mitochondrial Membranes
Cell Survival
cyclophilin D

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

The mitochondrial phosphate carrier : Role in oxidative metabolism, calcium handling and mitochondrial disease. / Seifert, Erin L.; Ligeti, E.; Mayr, Johannes A.; Sondheimer, Neal; Hajnóczky, György.

In: Biochemical and Biophysical Research Communications, Vol. 464, No. 2, 30.07.2015, p. 369-375.

Research output: Contribution to journalArticle

Seifert, Erin L. ; Ligeti, E. ; Mayr, Johannes A. ; Sondheimer, Neal ; Hajnóczky, György. / The mitochondrial phosphate carrier : Role in oxidative metabolism, calcium handling and mitochondrial disease. In: Biochemical and Biophysical Research Communications. 2015 ; Vol. 464, No. 2. pp. 369-375.
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