The methylenetetrahydrofolate reductase gene polymorphism (C677T) is associated with increased cardiovascular mortality in Hungary

Ákos Kalina, Andrew E. Czeizel

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The gene for methylenetetrahydrofolate reductase (MTHFR) has two different alleles (C and T), where the T is associated with decreased enzyme activity, hyperhomocysteinaemia, and increased risk for thromboembolism in coronary heart disease (CHD). The study was conducted using a sample of 378 Hungarian newborn infants: 96 control subjects (age: 59.9±8.6 years) with chest pain and 315 CHD patients (61.4±7.5 years). All adult subjects had undergone coronary angiography. It can be concluded that the carriers of T allele with CHD died earlier due to myocardial infarction and the C allele with lower homocysteine level may provide protection against fatal coronary artery occlusion.

Original languageEnglish
Pages (from-to)333-334
Number of pages2
JournalInternational Journal of Cardiology
Volume97
Issue number2
DOIs
Publication statusPublished - Nov 1 2004

Keywords

  • Coronary heart disease
  • Hyperhomocysteinaemia
  • Methylenetetrahydrofolate reductase
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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