The metabolism of azidomorphine in the rat

J. Knoll, G. Zsilla, S. Makleit

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Abstract

The metabolism of [7,8 3H]azidomorphine and the in vivo stability of the azido group in azidomorphine and 14 hydroxyazidomorphine was studied. Azidomorphine conjugates with glucuronic acid, and is N methylated by rat liver microsomes. Detection by means of infrared spectroscopy proved that the azido group in azidomorphine and 14 hydroxyazidomorphine strongly resists biotransformation in the rat.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalMedical biology
Volume53
Issue number6
Publication statusPublished - Dec 1 1975

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ASJC Scopus subject areas

  • Medicine(all)

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