The metabolism of [7,8 3H]azidomorphine and the in vivo stability of the azido group in azidomorphine and 14 hydroxyazidomorphine was studied. Azidomorphine conjugates with glucuronic acid, and is N methylated by rat liver microsomes. Detection by means of infrared spectroscopy proved that the azido group in azidomorphine and 14 hydroxyazidomorphine strongly resists biotransformation in the rat.
|Number of pages||4|
|Publication status||Published - Dec 1 1975|
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