The metabolism of azidomorphine in the rat

J. Knoll, G. Zsilla, S. Makleit

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The metabolism of [7,8 3H]azidomorphine and the in vivo stability of the azido group in azidomorphine and 14 hydroxyazidomorphine was studied. Azidomorphine conjugates with glucuronic acid, and is N methylated by rat liver microsomes. Detection by means of infrared spectroscopy proved that the azido group in azidomorphine and 14 hydroxyazidomorphine strongly resists biotransformation in the rat.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalMedical Biology
Volume53
Issue number6
Publication statusPublished - 1975

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Glucuronic Acid
Liver Microsomes
Biotransformation
Spectrum Analysis
azidomorphine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The metabolism of azidomorphine in the rat. / Knoll, J.; Zsilla, G.; Makleit, S.

In: Medical Biology, Vol. 53, No. 6, 1975, p. 501-504.

Research output: Contribution to journalArticle

Knoll, J, Zsilla, G & Makleit, S 1975, 'The metabolism of azidomorphine in the rat', Medical Biology, vol. 53, no. 6, pp. 501-504.
Knoll, J. ; Zsilla, G. ; Makleit, S. / The metabolism of azidomorphine in the rat. In: Medical Biology. 1975 ; Vol. 53, No. 6. pp. 501-504.
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