The melanin-concentrating hormone system in human, rodent and avian brain

János Bencze, Krisztina Pocsai, Balázs Murnyák, Péter Attila Gergely, B. Juhász, Z. Szilvássy, T. Hortobágyi

Research output: Contribution to journalReview article

Abstract

Melanin-concentrating hormone (MCH) is a cyclic 19 amino acid orexigenic hypothalamic peptide. MCH is located in the lateral and dorsal hypothalamus, as well as in the zona incerta. In mammals MCH increases food intake, contributes to regulation of energy balance, temperature, reproductive function, endocrine homeostasis and biological rhythms. Several studies have proved the significance of MCH in obesity, diabetes and depression. Although the peptide is well-characterized in mouse models, much less is known about its functions in avians. In birds the MCH system especially in the lateral and basal hypothalamus has important connections to the limbic system and it coordinates the vegetative and endocrine functions, as well as the emotional behaviour. Pharmacological modulation of MCH system could contribute to the therapy of eating disorders and improve agricultural efficiency regarding avians. Reviewing the current knowledge on MCH system in human, rodents and avians may stimulate a new wave of studies in the field.

Original languageEnglish
Pages (from-to)264-269
Number of pages6
JournalOpen Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Rodentia
Brain
Lateral Hypothalamic Area
Cyclic Amino Acids
Limbic System
Peptides
Periodicity
melanin-concentrating hormone
Birds
Mammals
Homeostasis
Obesity
Eating
Pharmacology
Depression
Temperature

Keywords

  • Avians
  • Mammals
  • MCH receptors
  • Melanin-concentrating hormone (MCH)
  • Neuroanatomy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The melanin-concentrating hormone system in human, rodent and avian brain. / Bencze, János; Pocsai, Krisztina; Murnyák, Balázs; Gergely, Péter Attila; Juhász, B.; Szilvássy, Z.; Hortobágyi, T.

In: Open Medicine, Vol. 13, No. 1, 01.01.2018, p. 264-269.

Research output: Contribution to journalReview article

Bencze, János ; Pocsai, Krisztina ; Murnyák, Balázs ; Gergely, Péter Attila ; Juhász, B. ; Szilvássy, Z. ; Hortobágyi, T. / The melanin-concentrating hormone system in human, rodent and avian brain. In: Open Medicine. 2018 ; Vol. 13, No. 1. pp. 264-269.
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