The medical preoptic area and the hypothalamic arcuate nucleus participate in the neuronal mechanism of compensatory ovarian growth

I. Gerendai, R. T. Denkova

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The possible involvement of the medial preoptic area (MPOA) and of the hypothalamic arcuate nucleus in the development of compensatory ovarian hypertrophy in rats was studied. Unilateral injection of the neurotoxic drug, kainic acid into the MPOA or into the hypothalamic arcuate nucleus ipsilateral to unilateral ovariectomy prevented the compensatory growth of the remaining ovary. In contrast, when kainic acid administration and hemiovariectomy were performed on the opposite side, the usual compensatory hypertrophy developed. These findings add further data to the assumption that a pure neural mechanism participates in the development of compensatory ovarian hypertrophy and indicate that the MPOA and the arcuate nucleus are involved in this mechanism.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalNeuroendocrinology Letters
Issue number5
Publication statusPublished - Jan 1 1980


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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