The mechanism of the motor response to periarterial nerve stimulation in the small intestine of the rabbit

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Abstract

In the presence of guanethidine, periarterial nerve stimulation caused a frequency-dependent motor response in the rabbit isolated ileum. Tachyphylaxis to capsaicin greatly diminished the effect of periarterial stimulation; the remaining portion of the contractile response was susceptible to hexamethonium. The motor effect of periarterial stimulation is mediated by two diffferent mechanisms: one via parasympathetic preganglionic nerves and the other sensitive to capsaicin.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalBritish Journal of Pharmacology
Volume70
Issue number2
Publication statusPublished - 1980

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Capsaicin
Small Intestine
Rabbits
Tachyphylaxis
Guanethidine
Hexamethonium
Ileum

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "The mechanism of the motor response to periarterial nerve stimulation in the small intestine of the rabbit",
abstract = "In the presence of guanethidine, periarterial nerve stimulation caused a frequency-dependent motor response in the rabbit isolated ileum. Tachyphylaxis to capsaicin greatly diminished the effect of periarterial stimulation; the remaining portion of the contractile response was susceptible to hexamethonium. The motor effect of periarterial stimulation is mediated by two diffferent mechanisms: one via parasympathetic preganglionic nerves and the other sensitive to capsaicin.",
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N2 - In the presence of guanethidine, periarterial nerve stimulation caused a frequency-dependent motor response in the rabbit isolated ileum. Tachyphylaxis to capsaicin greatly diminished the effect of periarterial stimulation; the remaining portion of the contractile response was susceptible to hexamethonium. The motor effect of periarterial stimulation is mediated by two diffferent mechanisms: one via parasympathetic preganglionic nerves and the other sensitive to capsaicin.

AB - In the presence of guanethidine, periarterial nerve stimulation caused a frequency-dependent motor response in the rabbit isolated ileum. Tachyphylaxis to capsaicin greatly diminished the effect of periarterial stimulation; the remaining portion of the contractile response was susceptible to hexamethonium. The motor effect of periarterial stimulation is mediated by two diffferent mechanisms: one via parasympathetic preganglionic nerves and the other sensitive to capsaicin.

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