The mechanism of the inhibitory effect of progesterone on lymphocyte cytotoxicity: I. Progesterone-treated lymphocytes release a substance inhibiting cytotoxicity and prostaglandin synthesis

J. Szekeres-Bartho, F. Kilar, G. Falkay, V. Csernus, A. Török, A. S. Pacsa

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Progesterone-treated lymphocytes (generator lymphocytes) of healthy pregnant women release a nondialyzable factor that inhibits both cytotoxic activity and prostaglandin F2α synthesis of test lymphocytes. Production of this factor is blocked by protein synthesis inhibitors (cycloheximide and actinomycin D). Sodium dodecylsulfate polyacrylamide electrophoresis of the partially purified material revealed a main 34,000 MW protein band. Progesterone-treated lymphocytes of pregnant women showing clinical symptoms of threatened preterm delivery (risk group) failed to release this substance.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalAmerican Journal of Reproductive Immunology and Microbiology
Issue number1
Publication statusPublished - Jan 1 1985


ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

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