The mechanism of blood pressure variability - Study in patients with fixed ventricular pacemaker rhythm

A. Kardos, L. Rudas, Z. Gingl, S. Szabados, J. Simon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Several studies have shown that heart rate variability plays an anti-oscillatory role in the regulation of blood pressure variability in humans. We tested whether systolic blood pressure variability in patients with a fixed ventricular pacemaker rhythm differs from that in patients with sinus rhythm. Methods and Results: In 18 patients with a fixed ventricular pacemaker rhythm and in ten age-matched patients with sinus rhythm the systolic blood pressure oscillation and the low and high-frequency spectral components of systolic blood pressure were studied in the resting supine position during spontaneous breathing and during forced deep ventilation of 6 cycles · min-1. Patients with a pacemaker had a higher amplitude of systolic blood pressure oscillation than control subjects during spontaneous breathing (13.5 ± 2.0 mmHg vs 6.4 ± 1.6 mmHg, P=0.035), and a slight but not significant difference also persisted during forced deep ventilation (19.0 ± 2-3 mmHg vs 15.0 ± 2-3 mmHg, P=0.18). The increment in systolic blood pressure fluctuation from spontaneous breathing to forced deep ventilation was less marked in the pacemaker group than in the control subjects (40% vs 130%, P=0.43). Although all the systolic blood pressure spectral components of the pacemaker patients were higher during both spontaneous breathing and forced deep ventilation, the differences between the two groups did not reach statistical significance. Conclusions: Our observations in patients with a fixed ventricular pacemaker rhythm suggest that the mechanical effects on the intrathoracic vessels and the consecutive stroke volume changes are responsible for respiration-related systolic blood pressure oscillation and reflex systolic blood pressure changes.

Original languageEnglish
Pages (from-to)545-552
Number of pages8
JournalEuropean Heart Journal
Volume16
Issue number4
Publication statusPublished - 1995

Fingerprint

Pacemakers
Blood pressure
Blood Pressure
Ventilation
Respiration
Oscillation
Heart Rate Variability
Statistical Significance
Stroke
Vessel
Increment
Low Frequency
Consecutive
Fluctuations
Cycle
Supine Position

Keywords

  • Blood pressure spectral analysis
  • Fixed ventricular pacemaker rhythm
  • Human study

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Cite this

The mechanism of blood pressure variability - Study in patients with fixed ventricular pacemaker rhythm. / Kardos, A.; Rudas, L.; Gingl, Z.; Szabados, S.; Simon, J.

In: European Heart Journal, Vol. 16, No. 4, 1995, p. 545-552.

Research output: Contribution to journalArticle

@article{980cf39723194802b47969dca3d4dc63,
title = "The mechanism of blood pressure variability - Study in patients with fixed ventricular pacemaker rhythm",
abstract = "Background: Several studies have shown that heart rate variability plays an anti-oscillatory role in the regulation of blood pressure variability in humans. We tested whether systolic blood pressure variability in patients with a fixed ventricular pacemaker rhythm differs from that in patients with sinus rhythm. Methods and Results: In 18 patients with a fixed ventricular pacemaker rhythm and in ten age-matched patients with sinus rhythm the systolic blood pressure oscillation and the low and high-frequency spectral components of systolic blood pressure were studied in the resting supine position during spontaneous breathing and during forced deep ventilation of 6 cycles · min-1. Patients with a pacemaker had a higher amplitude of systolic blood pressure oscillation than control subjects during spontaneous breathing (13.5 ± 2.0 mmHg vs 6.4 ± 1.6 mmHg, P=0.035), and a slight but not significant difference also persisted during forced deep ventilation (19.0 ± 2-3 mmHg vs 15.0 ± 2-3 mmHg, P=0.18). The increment in systolic blood pressure fluctuation from spontaneous breathing to forced deep ventilation was less marked in the pacemaker group than in the control subjects (40{\%} vs 130{\%}, P=0.43). Although all the systolic blood pressure spectral components of the pacemaker patients were higher during both spontaneous breathing and forced deep ventilation, the differences between the two groups did not reach statistical significance. Conclusions: Our observations in patients with a fixed ventricular pacemaker rhythm suggest that the mechanical effects on the intrathoracic vessels and the consecutive stroke volume changes are responsible for respiration-related systolic blood pressure oscillation and reflex systolic blood pressure changes.",
keywords = "Blood pressure spectral analysis, Fixed ventricular pacemaker rhythm, Human study",
author = "A. Kardos and L. Rudas and Z. Gingl and S. Szabados and J. Simon",
year = "1995",
language = "English",
volume = "16",
pages = "545--552",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - The mechanism of blood pressure variability - Study in patients with fixed ventricular pacemaker rhythm

AU - Kardos, A.

AU - Rudas, L.

AU - Gingl, Z.

AU - Szabados, S.

AU - Simon, J.

PY - 1995

Y1 - 1995

N2 - Background: Several studies have shown that heart rate variability plays an anti-oscillatory role in the regulation of blood pressure variability in humans. We tested whether systolic blood pressure variability in patients with a fixed ventricular pacemaker rhythm differs from that in patients with sinus rhythm. Methods and Results: In 18 patients with a fixed ventricular pacemaker rhythm and in ten age-matched patients with sinus rhythm the systolic blood pressure oscillation and the low and high-frequency spectral components of systolic blood pressure were studied in the resting supine position during spontaneous breathing and during forced deep ventilation of 6 cycles · min-1. Patients with a pacemaker had a higher amplitude of systolic blood pressure oscillation than control subjects during spontaneous breathing (13.5 ± 2.0 mmHg vs 6.4 ± 1.6 mmHg, P=0.035), and a slight but not significant difference also persisted during forced deep ventilation (19.0 ± 2-3 mmHg vs 15.0 ± 2-3 mmHg, P=0.18). The increment in systolic blood pressure fluctuation from spontaneous breathing to forced deep ventilation was less marked in the pacemaker group than in the control subjects (40% vs 130%, P=0.43). Although all the systolic blood pressure spectral components of the pacemaker patients were higher during both spontaneous breathing and forced deep ventilation, the differences between the two groups did not reach statistical significance. Conclusions: Our observations in patients with a fixed ventricular pacemaker rhythm suggest that the mechanical effects on the intrathoracic vessels and the consecutive stroke volume changes are responsible for respiration-related systolic blood pressure oscillation and reflex systolic blood pressure changes.

AB - Background: Several studies have shown that heart rate variability plays an anti-oscillatory role in the regulation of blood pressure variability in humans. We tested whether systolic blood pressure variability in patients with a fixed ventricular pacemaker rhythm differs from that in patients with sinus rhythm. Methods and Results: In 18 patients with a fixed ventricular pacemaker rhythm and in ten age-matched patients with sinus rhythm the systolic blood pressure oscillation and the low and high-frequency spectral components of systolic blood pressure were studied in the resting supine position during spontaneous breathing and during forced deep ventilation of 6 cycles · min-1. Patients with a pacemaker had a higher amplitude of systolic blood pressure oscillation than control subjects during spontaneous breathing (13.5 ± 2.0 mmHg vs 6.4 ± 1.6 mmHg, P=0.035), and a slight but not significant difference also persisted during forced deep ventilation (19.0 ± 2-3 mmHg vs 15.0 ± 2-3 mmHg, P=0.18). The increment in systolic blood pressure fluctuation from spontaneous breathing to forced deep ventilation was less marked in the pacemaker group than in the control subjects (40% vs 130%, P=0.43). Although all the systolic blood pressure spectral components of the pacemaker patients were higher during both spontaneous breathing and forced deep ventilation, the differences between the two groups did not reach statistical significance. Conclusions: Our observations in patients with a fixed ventricular pacemaker rhythm suggest that the mechanical effects on the intrathoracic vessels and the consecutive stroke volume changes are responsible for respiration-related systolic blood pressure oscillation and reflex systolic blood pressure changes.

KW - Blood pressure spectral analysis

KW - Fixed ventricular pacemaker rhythm

KW - Human study

UR - http://www.scopus.com/inward/record.url?scp=0029043675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029043675&partnerID=8YFLogxK

M3 - Article

C2 - 7671902

AN - SCOPUS:0029043675

VL - 16

SP - 545

EP - 552

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 4

ER -