The luteinizing hormone releasing hormone-containing pathways and their co-termination with tanycyte processes in and around the median eminence and in the pituitary stalk of the rat

M. Rethelyi, S. Vigh, G. Setalo, I. Merchenthaler, B. Flerkó, P. Petrusz

Research output: Contribution to journalArticle

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Abstract

The origin, course and termination of two luteinizing hormone-releasing hormone (LH-RH)-containing pathways were studied in the brain of rats by immunohistochemistry. In addition, the joint termination of LH-RH-containing nerve terminals and tanycyte processes over a rostro-caudally elongated belt surrounding the median eminence (ME) is described. The preoptico-infundibular tract originates from neurons confined to a pyramid-shaped area between the anterior commissure, the organum vasculosum laminae terminmalis (OVLT) and the most caudal level of the suprachiasmatic nucleus (SCH). The axons of these neurons from three fascicles. Fibres of the median fascicle run in caudal direction on the dorsal and ventral surfaces of the optic chiasma. Fibers of the medial fascicle run along the lateral border of the SCH towards the retrochiasmatic area. Fibres of the lateral fascicle course laterally in close contact with the concave dorsomedial surface of the optic tract. These latter fibres gradually turn in medial direction and reach the lateral margin of the ME. The caudal LH-RH fibre tract was characterized only partially because the perikarya giving rise to these fibres were not identified. The fibres run rostrally among the ependymal cells of the mesencephalic aqueduct and form two fascicles. The fibres of the mammillary fascicle enter, and seem to terminate, in the medial mammillary nucleus, while the fibres of the tuberal fascicle course rostrally and join the fibres of the preoptico-imfundibular tract. The surface areas of the brain along with LH-RH fibres terminate (retrochiasmatic area; inframammillary region, lateral margin of the ME) were found to display a special surface covering formed by tanycyte processes. The course of the LH-RH fibre tracts described here is in good agreement with earlier experimental results on the localization of neural pathways controlling ovulation and the secretion of pituitary gonadotropic hormones. The significance of the joint termination of LH-RH fibres and tanycyte processes, especially in areas where portal capillaries are absent, remains unclear.

Original languageEnglish
Pages (from-to)259-283
Number of pages25
JournalActa Morphologica Academiae Scientiarum Hungaricae
Volume29
Issue number2-3
Publication statusPublished - 1981

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Median Eminence
Pituitary Gland
Gonadotropin-Releasing Hormone
Suprachiasmatic Nucleus
Cerebral Aqueduct
Joints
Optic Chiasm
Neurons
Neural Pathways
Pituitary Hormones
Brain
Ovulation
Axons
Immunohistochemistry

ASJC Scopus subject areas

  • Anatomy

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The luteinizing hormone releasing hormone-containing pathways and their co-termination with tanycyte processes in and around the median eminence and in the pituitary stalk of the rat. / Rethelyi, M.; Vigh, S.; Setalo, G.; Merchenthaler, I.; Flerkó, B.; Petrusz, P.

In: Acta Morphologica Academiae Scientiarum Hungaricae, Vol. 29, No. 2-3, 1981, p. 259-283.

Research output: Contribution to journalArticle

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