The LPS receptor (CD14) links innate immunity with Alzheimer's disease.

K. Fassbender, S. Walter, S. Kühl, R. Landmann, K. Ishii, T. Bertsch, A. K. Stalder, F. Muehlhauser, Y. Liu, A. J. Ulmer, S. Rivest, A. Lentschat, E. Gulbins, M. Jucker, M. Staufenbiel, K. Brechtel, J. Walter, G. Multhaup, B. Penke, Y. AdachiT. Hartmann, K. Beyreuther

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

To rapidly respond to invading microorganisms, humans call on their innate immune system. This occurs by microbe-detecting receptors, such as CD14, that activate immune cells to eliminate the pathogens. Here, we link the lipopolysaccharide receptor CD14 with Alzheimer's disease, a severe neurodegenerative disease resulting in dementia. We demonstrate that this key innate immunity receptor interacts with fibrils of Alzheimer amyloid peptide. Neutralization with antibodies against CD14 and genetic deficiency for this receptor significantly reduced amyloid peptide induced microglial activation and microglial toxicity. The observation of strongly enhanced microglial expression of the LPS receptor in brains of animal models of Alzheimer's disease indicates a clinical relevance of these findings. These data suggest that CD14 may significantly contribute to the overall neuroinflammatory response to amyloid peptide, highlighting the possibility that the enormous progress currently being made in the field of innate immunity could be extended to research on Alzheimer's disease.

Original languageEnglish
Pages (from-to)203-205
Number of pages3
JournalFASEB Journal
Volume18
Issue number1
Publication statusPublished - 2004

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CD14 Antigens
Amyloid
Innate Immunity
Alzheimer Disease
Peptides
Neurodegenerative diseases
Immune system
Pathogens
Neurodegenerative Diseases
Microorganisms
Toxicity
Dementia
Immune System
Brain
Animals
Animal Models
Chemical activation
Observation
Antibodies
Research

Cite this

Fassbender, K., Walter, S., Kühl, S., Landmann, R., Ishii, K., Bertsch, T., ... Beyreuther, K. (2004). The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB Journal, 18(1), 203-205.

The LPS receptor (CD14) links innate immunity with Alzheimer's disease. / Fassbender, K.; Walter, S.; Kühl, S.; Landmann, R.; Ishii, K.; Bertsch, T.; Stalder, A. K.; Muehlhauser, F.; Liu, Y.; Ulmer, A. J.; Rivest, S.; Lentschat, A.; Gulbins, E.; Jucker, M.; Staufenbiel, M.; Brechtel, K.; Walter, J.; Multhaup, G.; Penke, B.; Adachi, Y.; Hartmann, T.; Beyreuther, K.

In: FASEB Journal, Vol. 18, No. 1, 2004, p. 203-205.

Research output: Contribution to journalArticle

Fassbender, K, Walter, S, Kühl, S, Landmann, R, Ishii, K, Bertsch, T, Stalder, AK, Muehlhauser, F, Liu, Y, Ulmer, AJ, Rivest, S, Lentschat, A, Gulbins, E, Jucker, M, Staufenbiel, M, Brechtel, K, Walter, J, Multhaup, G, Penke, B, Adachi, Y, Hartmann, T & Beyreuther, K 2004, 'The LPS receptor (CD14) links innate immunity with Alzheimer's disease.', FASEB Journal, vol. 18, no. 1, pp. 203-205.
Fassbender K, Walter S, Kühl S, Landmann R, Ishii K, Bertsch T et al. The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB Journal. 2004;18(1):203-205.
Fassbender, K. ; Walter, S. ; Kühl, S. ; Landmann, R. ; Ishii, K. ; Bertsch, T. ; Stalder, A. K. ; Muehlhauser, F. ; Liu, Y. ; Ulmer, A. J. ; Rivest, S. ; Lentschat, A. ; Gulbins, E. ; Jucker, M. ; Staufenbiel, M. ; Brechtel, K. ; Walter, J. ; Multhaup, G. ; Penke, B. ; Adachi, Y. ; Hartmann, T. ; Beyreuther, K. / The LPS receptor (CD14) links innate immunity with Alzheimer's disease. In: FASEB Journal. 2004 ; Vol. 18, No. 1. pp. 203-205.
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