The local structures of Cu(II) and Zn(II) complexes of hyaluronate

L. Nagy, S. Yamashita, T. Yamaguchi, P. Sipos, H. Wakita, M. Nomura

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51 Citations (Scopus)

Abstract

Cu(II) and Zn(II) complexes of hyaluronate (Hy) were prepared. The local structures and binding sites were determined by Cu and Zn K-EXAFS and XANES measurements in the solid state. Both metal ions were found to be coordinated to Hy via carboxylate and oxygen atoms and probably O-1. The NH group of the acetamido moiety does not take part in the complexation. Analysis of the EXAFS spectra revealed that the oxygen coordination geometry around the Cu(II) ion (distorted octahedron) and the Cu-O bond length (r(eq) = 200 pm) in the Cu(II)-Hy complex are not very different from those in the hexaaqua Cu(II) ion (195 pm). The Zn(II)-Hy complex is tetra coordinated in a tetrahedral structure, with an average Zn-O bond length of 202 pm. The nonbonding Cu...C and Zn...C distances were determined to be 315 and 299 pm, respectively. These values and the large Debye-Waller factors indicate the macrochelate coordination mode of the ligand.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalJournal of Inorganic Biochemistry
Volume72
Issue number1-2
DOIs
Publication statusPublished - Oct 1998

Keywords

  • Complex
  • Copper(II)
  • EXAFS
  • Hyaluronate
  • Local structure
  • Zinc(II)

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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