The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning

A. Végh, J. Papp, L. Szekeres, J. Parratt

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Short periods of coronary artery occlusion (2 x 5 min) markedly reduce the severity of arrhythmias and the changes in ST-segment elevation and in the degree of inhomogeneity of conduction during a subsequent 25 min occlusion of the left anterior descending coronary artery in anaesthetized dogs. These changes were completely reversed if methylene blue (5 mg min-1) was infused into a side branch of the coronary artery throughout both the preconditioning and prolonged occlusions. These results suggest that the pronounced antiarrhythmic effects of preconditioning result from activation of guanylyl cyclase and result in increased levels of guanosine 3':5'-cyclic monophosphate.

Original languageEnglish
Pages (from-to)910-911
Number of pages2
JournalBritish Journal of Pharmacology
Volume107
Issue number4
Publication statusPublished - 1992

Fingerprint

Ischemic Preconditioning
Methylene Blue
Coronary Vessels
Guanosine
Guanylate Cyclase
Coronary Occlusion
Cardiac Arrhythmias
Dogs

Keywords

  • Cyclic GMP
  • Guanyl cyclase
  • Ischaemic preconditioning
  • Methylene blue
  • Nitric oxide
  • Reperfusions
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "Short periods of coronary artery occlusion (2 x 5 min) markedly reduce the severity of arrhythmias and the changes in ST-segment elevation and in the degree of inhomogeneity of conduction during a subsequent 25 min occlusion of the left anterior descending coronary artery in anaesthetized dogs. These changes were completely reversed if methylene blue (5 mg min-1) was infused into a side branch of the coronary artery throughout both the preconditioning and prolonged occlusions. These results suggest that the pronounced antiarrhythmic effects of preconditioning result from activation of guanylyl cyclase and result in increased levels of guanosine 3':5'-cyclic monophosphate.",
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T1 - The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning

AU - Végh, A.

AU - Papp, J.

AU - Szekeres, L.

AU - Parratt, J.

PY - 1992

Y1 - 1992

N2 - Short periods of coronary artery occlusion (2 x 5 min) markedly reduce the severity of arrhythmias and the changes in ST-segment elevation and in the degree of inhomogeneity of conduction during a subsequent 25 min occlusion of the left anterior descending coronary artery in anaesthetized dogs. These changes were completely reversed if methylene blue (5 mg min-1) was infused into a side branch of the coronary artery throughout both the preconditioning and prolonged occlusions. These results suggest that the pronounced antiarrhythmic effects of preconditioning result from activation of guanylyl cyclase and result in increased levels of guanosine 3':5'-cyclic monophosphate.

AB - Short periods of coronary artery occlusion (2 x 5 min) markedly reduce the severity of arrhythmias and the changes in ST-segment elevation and in the degree of inhomogeneity of conduction during a subsequent 25 min occlusion of the left anterior descending coronary artery in anaesthetized dogs. These changes were completely reversed if methylene blue (5 mg min-1) was infused into a side branch of the coronary artery throughout both the preconditioning and prolonged occlusions. These results suggest that the pronounced antiarrhythmic effects of preconditioning result from activation of guanylyl cyclase and result in increased levels of guanosine 3':5'-cyclic monophosphate.

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KW - Guanyl cyclase

KW - Ischaemic preconditioning

KW - Methylene blue

KW - Nitric oxide

KW - Reperfusions

KW - Ventricular arrhythmias

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