The load of genetic and partially genetic diseases in man III. Mental retardation

E. Czeizel, K. Sankaranarayanan, M. Szondy

Research output: Contribution to journalArticle

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Abstract

This paper summarizes estimates of detriment associated with different etiologic categories of mental retardation (MR) in Hungary. The basic date drive from an earlier study carried out in Budapest on 1276 school-age mentally retarded children (with some etiologic reclassification based on recent studies). Detriment associated with these categories of MR is expressed in terms of years of lost and impaired life. About 30 per 103 school-age children in Hungary are mentally retarded (mild + severe MR), one-tenth of whom have severe MR (IQ ≤ 50); 50% of the latter are institutuinalized. The breakdown on the basis of etiology is as followsL: gene mutations and chromosomal abnormalities, about 4 per 10z3; 'familial' (multifactorial) causes, 12 per 103; adverse pre-, peri- and post-natal causes, 11 per 103; and 'causes as yet unknown', the remainder. The estimates of mean number of years of lost life range from 42 to 68 (depending on the etiologic category), with an overall mean of 58. The total number of years of lost life is about 36 000 per 104 live births of which over 70% is due to pre-, peri- and post-natal causes, 18% due to 'familial' causes and the remainder due to Mendelian and chromosomal diseases. The total number of years of impaired life is about 7300 per 104 livebirths, 50% of which is due to 'familial' causes. While admittedly approximate, these estimates suggest that detriment associated wtih MR-related causes is not inconsiderabel. Additionally, the provide some indication of causes of MR which are minimizable.

Original languageEnglish
Pages (from-to)291-303
Number of pages13
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume232
Issue number2
DOIs
Publication statusPublished - 1990

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Genetic Load
Inborn Genetic Diseases
Intellectual Disability
Hungary
Mentally Disabled Persons
Live Birth
Chromosome Aberrations
Mutation

Keywords

  • Detriment
  • Hungary
  • Mental retardation

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

The load of genetic and partially genetic diseases in man III. Mental retardation. / Czeizel, E.; Sankaranarayanan, K.; Szondy, M.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 232, No. 2, 1990, p. 291-303.

Research output: Contribution to journalArticle

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