The load of genetic and partially genetic diseases in man. II. Some selected common multifactorial diseases: Estimates of population prevalence and of detriment in terms of years of lost and impaired life

A. Czeizel, K. Sankaranarayanan, A. Losonci, T. Rudas, M. Keresztes

Research output: Contribution to journalReview article

21 Citations (Scopus)


This paper presents epidemiological data on the prevalence of 26 common (i.e., having a lifetime prevalence of more than 1 per 104 individuals in the population) multifactorial diseases in Hungary and estimates of detriment associated with them. The detriment is expressed using 3 indicators, namely years of lost life (LL), potentially impaired life (PIL) and actually impaired life (AIL). The total prevalence of these diseases in Hungary has been estimated to be about 6500 per 104 individuals in the population. This estimate is in agreement with published data for other parts of the world. On the basis of clinical severity, these diseases have been split into 3 groups, namely (1) very severe (schizophrenia, multiple sclerosis, epilepsy, acute myocardial infarction and related conditions, and systemic lupus erythematosus); (2) moderately severe and/or episodal or seasonal (15 entities including Graves' disease, diabetes mellitus, gout, affective psychoses, essential hypertension, peptic ulcers, asthma, etc.); and (3) less severe than those in the first 2 groups (varicose veins, allergic rhinitis, atopic dermatitis, Scheuermann disease and adolescent idiopathic scoliosis). The essential clinical and genetic aspects of these diseases are briefly discussed. With the exception of epilepsy, none of the diseases included in our list causes mortality between ages 0 and 19. However, they are among the leading causes of death between ages 20 and 69 and thereafter. A sizeable proportion of those with essential hypertension, diabetes mellitus, rheumatoid arthritis, etc. survive to 70 years and beyond, as do those with gout, glaucoma, allergic rhinitis, psoriasis, etc. Overall, about 16% of all deaths that occur in Hungary every year (all age groups) can be attributed to these diseases.

Original languageEnglish
Pages (from-to)259-292
Number of pages34
JournalMutation Research/Reviews in Genetic Toxicology
Issue number3
Publication statusPublished - Nov 1988



  • Multifactorial diseases
  • Population prevalence
  • Years of impaired life
  • Years of lost life

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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