The lateral hypothalamus: A site for integration of nutrient and fluid balance

Gertjan Van Dijk, Simon S. Evers, Stefano Guidotti, Simon N. Thornton, Anton J W Scheurink, C. Nyakas

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This paper reviews seemingly obligatory relations between nutrient and fluid balance. A relatively novel neuronal pathway involving interplay between acetylcholine and the melanocortins, αMSH and AGRP in the arcuate nucleus (Arc) of the hypothalamus projecting to the lateral hypothalamus (LH) may bridge this gap. In the fasted condition, increased expression of MCH (due to muscarinic-3 receptor stimulation and low melanocortin tone) and neuronal release of MCH (via Orexin signaling) underlies a drive towards positive energy balance, increased B cell capacity to secrete insulin, and this is associated with optimal fluid homeostasis. A hypohydrated state is hypothesized to yield downregulation of leptin signaling (potentially via inhibitory effects of osmotic stress on mTOR), but osmotic stress may prevent MCH expression via the OVLT-SFO complex. If this occurs in an obese state, impaired pancreatic B cell capacity and peripheral insulin insensitivity as a result of hypohydration may underlie cardio-metabolic diseases.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalBehavioural Brain Research
Volume221
Issue number2
DOIs
Publication statusPublished - Aug 10 2011

Fingerprint

Melanocortins
Lateral Hypothalamic Area
Water-Electrolyte Balance
Osmotic Pressure
Insulin
Melanocyte-Stimulating Hormones
Food
Arcuate Nucleus of Hypothalamus
Metabolic Diseases
Insulin-Secreting Cells
Muscarinic Receptors
Leptin
Acetylcholine
Homeostasis
B-Lymphocytes
Down-Regulation

Keywords

  • Body water
  • Drinking
  • Feeding
  • Insulin
  • Obesity
  • Osmotic stress

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Van Dijk, G., Evers, S. S., Guidotti, S., Thornton, S. N., Scheurink, A. J. W., & Nyakas, C. (2011). The lateral hypothalamus: A site for integration of nutrient and fluid balance. Behavioural Brain Research, 221(2), 481-487. https://doi.org/10.1016/j.bbr.2011.01.047

The lateral hypothalamus : A site for integration of nutrient and fluid balance. / Van Dijk, Gertjan; Evers, Simon S.; Guidotti, Stefano; Thornton, Simon N.; Scheurink, Anton J W; Nyakas, C.

In: Behavioural Brain Research, Vol. 221, No. 2, 10.08.2011, p. 481-487.

Research output: Contribution to journalArticle

Van Dijk, G, Evers, SS, Guidotti, S, Thornton, SN, Scheurink, AJW & Nyakas, C 2011, 'The lateral hypothalamus: A site for integration of nutrient and fluid balance', Behavioural Brain Research, vol. 221, no. 2, pp. 481-487. https://doi.org/10.1016/j.bbr.2011.01.047
Van Dijk, Gertjan ; Evers, Simon S. ; Guidotti, Stefano ; Thornton, Simon N. ; Scheurink, Anton J W ; Nyakas, C. / The lateral hypothalamus : A site for integration of nutrient and fluid balance. In: Behavioural Brain Research. 2011 ; Vol. 221, No. 2. pp. 481-487.
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