The lambeth conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias

Michael J. Curtis, Jules C. Hancox, András Farkas, Cherry L. Wainwright, Catherine L. Stables, David A. Saint, Hugh Clements-Jewery, Pier D. Lambiase, George E. Billman, Michiel J. Janse, Michael K. Pugsley, G. André Ng, Dan M. Roden, A. John Camm, Michael J.A. Walker

Research output: Contribution to journalReview article

154 Citations (Scopus)

Abstract

The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988), intended to be of practical value in the investigation of experimental arrhythmias induced by ischaemia, infarction, and reperfusion. This is an update, expanded to include guidance on the study of supraventricular arrhythmias, drug-induced arrhythmias, heritable arrhythmias, and advances in our knowledge in core areas since 1987. We have updated the guidance on the design and execution of experiments and the definition, classification, quantification, and analysis of all types of arrhythmias. Investigators are encouraged to adopt the conventions and test their validity in the hope that this will improve uniformity and interlaboratory comparisons, aid clinical research, facilitate antiarrhythmic drug discovery and safety assessment, and improve antiarrhythmic drug deployment for different cardiac conditions. We note that there is a gap between some definitions proposed here and their conventional clinical counterparts, and encourage the research necessary to bridge that translational gap. A web link offers the chance to vote and comment on the new conventions (https://bscr.wufoo.com/forms/z7x0x5/).

Original languageEnglish
Pages (from-to)213-248
Number of pages36
JournalPharmacology and Therapeutics
Volume139
Issue number2
DOIs
Publication statusPublished - Aug 1 2013

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Keywords

  • Antiarrhythmic
  • Lambeth Conventions
  • Methods
  • Supraventricular arrhythmia
  • Torsades de pointes
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Curtis, M. J., Hancox, J. C., Farkas, A., Wainwright, C. L., Stables, C. L., Saint, D. A., Clements-Jewery, H., Lambiase, P. D., Billman, G. E., Janse, M. J., Pugsley, M. K., Ng, G. A., Roden, D. M., Camm, A. J., & Walker, M. J. A. (2013). The lambeth conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacology and Therapeutics, 139(2), 213-248. https://doi.org/10.1016/j.pharmthera.2013.04.008