The L-type calcium channel in the heart

The beat goes on

Ilona Bodi, G. Mikala, Sheryl E. Koch, Shahab A. Akhter, Arnold Schwartz

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.

Original languageEnglish
Pages (from-to)3306-3317
Number of pages12
JournalJournal of Clinical Investigation
Volume115
Issue number12
DOIs
Publication statusPublished - Dec 2005

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L-Type Calcium Channels
Heart Diseases
Cardiomegaly
Sudden Death
Heart Failure

ASJC Scopus subject areas

  • Medicine(all)

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The L-type calcium channel in the heart : The beat goes on. / Bodi, Ilona; Mikala, G.; Koch, Sheryl E.; Akhter, Shahab A.; Schwartz, Arnold.

In: Journal of Clinical Investigation, Vol. 115, No. 12, 12.2005, p. 3306-3317.

Research output: Contribution to journalArticle

Bodi, I, Mikala, G, Koch, SE, Akhter, SA & Schwartz, A 2005, 'The L-type calcium channel in the heart: The beat goes on', Journal of Clinical Investigation, vol. 115, no. 12, pp. 3306-3317. https://doi.org/10.1172/JCI27167
Bodi, Ilona ; Mikala, G. ; Koch, Sheryl E. ; Akhter, Shahab A. ; Schwartz, Arnold. / The L-type calcium channel in the heart : The beat goes on. In: Journal of Clinical Investigation. 2005 ; Vol. 115, No. 12. pp. 3306-3317.
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