The key-role of vagal nerve and adrenals in the cytoprotection and general gastric mucosal integrity

G. Mózsik, Oszkár Karádi, Ágnes Király, András Debreceni, M. Figler, Lajos Nagy, A. Pár, G. Pár, G. Sütö, A. Vincze

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Our laboratory group observed earlier that the gastric mucosal cytoprotective effect of prostacyclin (PGI2) disappeared after surgical vagotomy in rats. Similarly to this, the beta-carotene induced gastric cytoprotection disappeared in adrenalectomized rats too. Aims: In these studies we aimed to investigate the possible role of vagal nerve and adrenals in the development of gastric mucosal lesions induced by exogenously administered chemicals (ethanol, HCl, NaOH, NaCl and indomethacin), and on the effects of cytoprotective and antisecretory drugs (atropine, cimetidine), and scavengers (vitamin A and β-carotene). Methods: The observations were carried out in fasted CFY strain rats. The gastric mucosal lesions were produced by intragastric (i.g.) administration of narcotising agents (96% ethanol; 0.6 M HCl; 0.2 M NaOH; 25% NaCl) or subcutaneously (s.c.) administered indomethacin (20 mg/kg) in intact, surgically bilaterally vagatomized, and adrenalectomized rats without or with glucocorticoid supplementation (Oradexon, 0.6 mg/kg given i.m. for 1 week). The gastric mucosal protective effect of antisecretory doses of atropine (0.1-0.5-1.0 mg/kg i.g.) and cimetidine (10-25-50 mg/kg i.g.), and vitamin A and β-carotene (0.01-0.1-1.0-10 mg/kg i.g.) was studied. The number and severity of mucosal gastric lesions was numerically or semiquantitatively measured. In other series of observations the gastric acid secretion and mucosal damage were studied in 24 h pylorus-ligated rats without and with acute bilateral surgical vagotomy. Results: It was found that: (1) the chemical-induced gastric mucosal damage was enhanced in vagotomized and adrenalectomized rats, meanwhile the endogenous secretion of gastric acid, and the development of mucosal damage can be prevented by surgical vagotomy; (2) the gastric cyto- and general protection produced by the drugs and scavengers disappeared in vagotomized and adrenalectomized rats; (3) the gastric mucosal protective effects of drugs and of scavengers returned after sufficient glucocorticoid supplementation of the rats. Conclusion: It has been concluded that the intact vagal nerve and adrenals have a key role in the gastric mucosal integrity, and in drugs- and scavengers-induced gastric cyto- and general mucosal protection.

Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - 2001

Fingerprint

Cytoprotection
Stomach
Vagotomy
Gastric Acid
Cimetidine
Epoprostenol
Carotenoids
Vitamin A
Atropine
Indomethacin
Glucocorticoids
Ethanol
Pharmaceutical Preparations
Protective Agents
Pylorus
beta Carotene
Dexamethasone

Keywords

  • β-carotene
  • Adrenalectomy
  • Adrenals
  • Atropine
  • Chemical-induced gastric mucosal damage
  • Cimetidine
  • Gastric cyto- and general protection
  • Glucocorticoid supplementation
  • Surgical vagotomy
  • Vagal nerve
  • Vitamin A

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

The key-role of vagal nerve and adrenals in the cytoprotection and general gastric mucosal integrity. / Mózsik, G.; Karádi, Oszkár; Király, Ágnes; Debreceni, András; Figler, M.; Nagy, Lajos; Pár, A.; Pár, G.; Sütö, G.; Vincze, A.

In: Journal of Physiology Paris, Vol. 95, No. 1-6, 2001, p. 229-237.

Research output: Contribution to journalArticle

@article{7acdeb9076ce4b62b3cedf905fb2a146,
title = "The key-role of vagal nerve and adrenals in the cytoprotection and general gastric mucosal integrity",
abstract = "Background: Our laboratory group observed earlier that the gastric mucosal cytoprotective effect of prostacyclin (PGI2) disappeared after surgical vagotomy in rats. Similarly to this, the beta-carotene induced gastric cytoprotection disappeared in adrenalectomized rats too. Aims: In these studies we aimed to investigate the possible role of vagal nerve and adrenals in the development of gastric mucosal lesions induced by exogenously administered chemicals (ethanol, HCl, NaOH, NaCl and indomethacin), and on the effects of cytoprotective and antisecretory drugs (atropine, cimetidine), and scavengers (vitamin A and β-carotene). Methods: The observations were carried out in fasted CFY strain rats. The gastric mucosal lesions were produced by intragastric (i.g.) administration of narcotising agents (96{\%} ethanol; 0.6 M HCl; 0.2 M NaOH; 25{\%} NaCl) or subcutaneously (s.c.) administered indomethacin (20 mg/kg) in intact, surgically bilaterally vagatomized, and adrenalectomized rats without or with glucocorticoid supplementation (Oradexon, 0.6 mg/kg given i.m. for 1 week). The gastric mucosal protective effect of antisecretory doses of atropine (0.1-0.5-1.0 mg/kg i.g.) and cimetidine (10-25-50 mg/kg i.g.), and vitamin A and β-carotene (0.01-0.1-1.0-10 mg/kg i.g.) was studied. The number and severity of mucosal gastric lesions was numerically or semiquantitatively measured. In other series of observations the gastric acid secretion and mucosal damage were studied in 24 h pylorus-ligated rats without and with acute bilateral surgical vagotomy. Results: It was found that: (1) the chemical-induced gastric mucosal damage was enhanced in vagotomized and adrenalectomized rats, meanwhile the endogenous secretion of gastric acid, and the development of mucosal damage can be prevented by surgical vagotomy; (2) the gastric cyto- and general protection produced by the drugs and scavengers disappeared in vagotomized and adrenalectomized rats; (3) the gastric mucosal protective effects of drugs and of scavengers returned after sufficient glucocorticoid supplementation of the rats. Conclusion: It has been concluded that the intact vagal nerve and adrenals have a key role in the gastric mucosal integrity, and in drugs- and scavengers-induced gastric cyto- and general mucosal protection.",
keywords = "β-carotene, Adrenalectomy, Adrenals, Atropine, Chemical-induced gastric mucosal damage, Cimetidine, Gastric cyto- and general protection, Glucocorticoid supplementation, Surgical vagotomy, Vagal nerve, Vitamin A",
author = "G. M{\'o}zsik and Oszk{\'a}r Kar{\'a}di and {\'A}gnes Kir{\'a}ly and Andr{\'a}s Debreceni and M. Figler and Lajos Nagy and A. P{\'a}r and G. P{\'a}r and G. S{\"u}t{\"o} and A. Vincze",
year = "2001",
doi = "10.1016/S0928-4257(01)00030-4",
language = "English",
volume = "95",
pages = "229--237",
journal = "Journal de Physiologie",
issn = "0928-4257",
publisher = "Elsevier Masson SAS",
number = "1-6",

}

TY - JOUR

T1 - The key-role of vagal nerve and adrenals in the cytoprotection and general gastric mucosal integrity

AU - Mózsik, G.

AU - Karádi, Oszkár

AU - Király, Ágnes

AU - Debreceni, András

AU - Figler, M.

AU - Nagy, Lajos

AU - Pár, A.

AU - Pár, G.

AU - Sütö, G.

AU - Vincze, A.

PY - 2001

Y1 - 2001

N2 - Background: Our laboratory group observed earlier that the gastric mucosal cytoprotective effect of prostacyclin (PGI2) disappeared after surgical vagotomy in rats. Similarly to this, the beta-carotene induced gastric cytoprotection disappeared in adrenalectomized rats too. Aims: In these studies we aimed to investigate the possible role of vagal nerve and adrenals in the development of gastric mucosal lesions induced by exogenously administered chemicals (ethanol, HCl, NaOH, NaCl and indomethacin), and on the effects of cytoprotective and antisecretory drugs (atropine, cimetidine), and scavengers (vitamin A and β-carotene). Methods: The observations were carried out in fasted CFY strain rats. The gastric mucosal lesions were produced by intragastric (i.g.) administration of narcotising agents (96% ethanol; 0.6 M HCl; 0.2 M NaOH; 25% NaCl) or subcutaneously (s.c.) administered indomethacin (20 mg/kg) in intact, surgically bilaterally vagatomized, and adrenalectomized rats without or with glucocorticoid supplementation (Oradexon, 0.6 mg/kg given i.m. for 1 week). The gastric mucosal protective effect of antisecretory doses of atropine (0.1-0.5-1.0 mg/kg i.g.) and cimetidine (10-25-50 mg/kg i.g.), and vitamin A and β-carotene (0.01-0.1-1.0-10 mg/kg i.g.) was studied. The number and severity of mucosal gastric lesions was numerically or semiquantitatively measured. In other series of observations the gastric acid secretion and mucosal damage were studied in 24 h pylorus-ligated rats without and with acute bilateral surgical vagotomy. Results: It was found that: (1) the chemical-induced gastric mucosal damage was enhanced in vagotomized and adrenalectomized rats, meanwhile the endogenous secretion of gastric acid, and the development of mucosal damage can be prevented by surgical vagotomy; (2) the gastric cyto- and general protection produced by the drugs and scavengers disappeared in vagotomized and adrenalectomized rats; (3) the gastric mucosal protective effects of drugs and of scavengers returned after sufficient glucocorticoid supplementation of the rats. Conclusion: It has been concluded that the intact vagal nerve and adrenals have a key role in the gastric mucosal integrity, and in drugs- and scavengers-induced gastric cyto- and general mucosal protection.

AB - Background: Our laboratory group observed earlier that the gastric mucosal cytoprotective effect of prostacyclin (PGI2) disappeared after surgical vagotomy in rats. Similarly to this, the beta-carotene induced gastric cytoprotection disappeared in adrenalectomized rats too. Aims: In these studies we aimed to investigate the possible role of vagal nerve and adrenals in the development of gastric mucosal lesions induced by exogenously administered chemicals (ethanol, HCl, NaOH, NaCl and indomethacin), and on the effects of cytoprotective and antisecretory drugs (atropine, cimetidine), and scavengers (vitamin A and β-carotene). Methods: The observations were carried out in fasted CFY strain rats. The gastric mucosal lesions were produced by intragastric (i.g.) administration of narcotising agents (96% ethanol; 0.6 M HCl; 0.2 M NaOH; 25% NaCl) or subcutaneously (s.c.) administered indomethacin (20 mg/kg) in intact, surgically bilaterally vagatomized, and adrenalectomized rats without or with glucocorticoid supplementation (Oradexon, 0.6 mg/kg given i.m. for 1 week). The gastric mucosal protective effect of antisecretory doses of atropine (0.1-0.5-1.0 mg/kg i.g.) and cimetidine (10-25-50 mg/kg i.g.), and vitamin A and β-carotene (0.01-0.1-1.0-10 mg/kg i.g.) was studied. The number and severity of mucosal gastric lesions was numerically or semiquantitatively measured. In other series of observations the gastric acid secretion and mucosal damage were studied in 24 h pylorus-ligated rats without and with acute bilateral surgical vagotomy. Results: It was found that: (1) the chemical-induced gastric mucosal damage was enhanced in vagotomized and adrenalectomized rats, meanwhile the endogenous secretion of gastric acid, and the development of mucosal damage can be prevented by surgical vagotomy; (2) the gastric cyto- and general protection produced by the drugs and scavengers disappeared in vagotomized and adrenalectomized rats; (3) the gastric mucosal protective effects of drugs and of scavengers returned after sufficient glucocorticoid supplementation of the rats. Conclusion: It has been concluded that the intact vagal nerve and adrenals have a key role in the gastric mucosal integrity, and in drugs- and scavengers-induced gastric cyto- and general mucosal protection.

KW - β-carotene

KW - Adrenalectomy

KW - Adrenals

KW - Atropine

KW - Chemical-induced gastric mucosal damage

KW - Cimetidine

KW - Gastric cyto- and general protection

KW - Glucocorticoid supplementation

KW - Surgical vagotomy

KW - Vagal nerve

KW - Vitamin A

UR - http://www.scopus.com/inward/record.url?scp=0034751094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034751094&partnerID=8YFLogxK

U2 - 10.1016/S0928-4257(01)00030-4

DO - 10.1016/S0928-4257(01)00030-4

M3 - Article

C2 - 11595442

AN - SCOPUS:0034751094

VL - 95

SP - 229

EP - 237

JO - Journal de Physiologie

JF - Journal de Physiologie

SN - 0928-4257

IS - 1-6

ER -