The Janus Face of Steric Effect in Lewis Acid Catalyst with Size-Exclusion Design. Steric Repulsion and Steric Attraction in Catalytic Exo-Selective Diels-Alder Reaction

Mária Bakos, Zoltán Dobi, Daniel Fegyverneki, Ádám Gyömöre, Israel Fernandez, T. Soós

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An exo-selective catalytic Diels-Alder reaction was developed using Lewis acid catalyst with size-exclusion structural design. Exploiting the steric effect, especially the steric attraction, the Lewis acid catalyst was able to reroute the reaction along a higher energy pathway. The experimental findings were also supported by theoretical calculations. This catalyst development allows an easy and practical access to highly complex and pharmaceutically relevant compounds.

Original languageEnglish
JournalACS Sustainable Chemistry and Engineering
DOIs
Publication statusAccepted/In press - May 11 2018

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ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment

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