An exo-selective catalytic Diels-Alder reaction was developed using Lewis acid catalyst with size-exclusion structural design. Exploiting the steric effect, especially the steric attraction, the Lewis acid catalyst was able to reroute the reaction along a higher energy pathway. The experimental findings were also supported by theoretical calculations. This catalyst development allows an easy and practical access to highly complex and pharmaceutically relevant compounds.
ASJC Scopus subject areas
- Environmental Chemistry
- Chemical Engineering(all)
- Renewable Energy, Sustainability and the Environment