The involvement of nitric oxide (NO) in the CGRP-induced behavior of rats

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The possible role of nitric oxide (NO) in CGRP-induced passive avoidance, active avoidance, and open field behavior was tested in rats. A specific NO synthase inhibitor, N(ω)-nitro-L-arginine (L-NA), was used to disrupt NO synthesis. ICV administration of 5 μg of L-NA reversed the action of CGRP in passive and active avoidance tests. In an open field, L-NA prevented the action of CGRP on locomotion and grooming. The inactive isomer D-NA had no effect on behavior of animals. The data suggest that NO might contribute to CGRP-induced behavior in rats.

Original languageEnglish
Pages (from-to)1183-1187
Number of pages5
JournalPeptides
Volume17
Issue number7
DOIs
Publication statusPublished - 1996

Fingerprint

Rats
Nitric Oxide
Grooming
Animal Behavior
Locomotion
Nitric Oxide Synthase
Isomers
Arginine
Animals

Keywords

  • CGRP
  • locomotor and grooming activity
  • NO
  • passive and active avoidance behavior
  • transmitters

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

The involvement of nitric oxide (NO) in the CGRP-induced behavior of rats. / Kovács, A.; Telegdy, G.; Tóth, G.; Penke, B.

In: Peptides, Vol. 17, No. 7, 1996, p. 1183-1187.

Research output: Contribution to journalArticle

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