The involvement of mitochondria in the pathogenesis of multiple sclerosis

B. Kálmán, Karen Laitinen, S. Komoly

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Multiple sclerosis is an immune-mediated disorder of the central nervous system. Major pathological characteristics include the loss of oligodendrocytes, demyelination and neuroaxonal depletion in association with inflammation. The complex pathophysiology of tissue loss is only partially understood. Here we discuss a variety of mitochondrion-driven mechanisms involved in immune regulation, oligodendrocyte depletion and neurodegeneration. The recognition of a mitochondrial link between inflammation and neurodegeneration underscores the importance of an early aggressive intervention for halting inflammation and preventing neurodegeneration, and identifies the mitochondrion as a potential target in neuroprotection.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalJournal of Neuroimmunology
Volume188
Issue number1-2
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Multiple Sclerosis
Mitochondria
Oligodendroglia
Inflammation
Immune System Diseases
Demyelinating Diseases
Central Nervous System
Neuroprotection

Keywords

  • Apoptosis
  • Inflammation
  • Mitochondrion
  • Multiple sclerosis
  • Neurodegeneration

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

The involvement of mitochondria in the pathogenesis of multiple sclerosis. / Kálmán, B.; Laitinen, Karen; Komoly, S.

In: Journal of Neuroimmunology, Vol. 188, No. 1-2, 08.2007, p. 1-12.

Research output: Contribution to journalArticle

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