The interleukin-8 receptor: a potential target for antipsoriatic therapy?

Lajos Kemény, Anna Sz Kenderessy, Edit Olasz, Günter Michel, Thomas Ruzicka, Beatrix Farkas, Attila Dobozy

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Interleukin-8 is assumed to play a central role in the pathogenesis of psoriasis. Since an increased expression of the interleukin-8 receptor has been observed both in polymorphonuclear leukocytes and in affected psoriatic epidermis, we were interested in whether the interleukin-8 receptor could be a molecular target of antipsoriatic compounds. Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected. In addition, the interleukin-8-induced human leukocyte antigen-DR (HLA-DR) expression of keratinocytes was nearly completely blocked by treatment of the cells with these substances. The inhibition of the keratinocyte interleukin-8 receptor and its function by antipsoriatic drugs may contribute to their therapeutic action.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalEuropean Journal of Pharmacology
Volume258
Issue number3
DOIs
Publication statusPublished - Jun 13 1994

Keywords

  • Calcitriol
  • Cyclosporine
  • Dithranol
  • Interleukin-8 receptor
  • Psoriasis

ASJC Scopus subject areas

  • Pharmacology

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