The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

Derek Sharples, Gabriella Spengler, Joseph Molnár, Zsuzsanna Antal, Annamária Molnár, János T. Kiss, József A. Szabó, Andreas Hilgeroth, Sandrine Gallo, Abdallah Mahamoud, Jacques Barbe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Aza-fluorenes
  • DNA interaction
  • MDR1 p-glycoprotein
  • Pregnanes
  • Pyridoquinolines
  • Transfer RNA interaction

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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