The insulin-like growth factor system

IGFs, IGF-binding proteins and IGFBP-proteases

A. Lelbach, G. Müzes, J. Fehér

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Insulin-like growth factors (IGF-I/-II) are not only the endocrine mediators of growth hormone-induced metabolic and anabolic actions but also polypeptides that act in a paracrine and autocrine manner to regulate cell growth, differentiation, apoptosis and transformation. The IGF system is a complex network comprised of two growth factors (IGF-I and -II), cell surface receptors (IGF-IR and -IIR), six specific high affinity binding proteins (IGFBP-1 to IGFBP-6), IGFBP proteases as well as several other IGFBP-interacting molecules, which regulate and propagate IGF actions in several tissues. Besides their broad-spectrum physiological and pathophysiological functions, recent evidence suggests even a link between IGFs and different malignancies.

Original languageEnglish
Pages (from-to)97-107
Number of pages11
JournalActa Physiologica Hungarica
Volume92
Issue number2
DOIs
Publication statusPublished - 2005

Fingerprint

Insulin-Like Growth Factor Binding Proteins
Somatomedins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Peptide Hydrolases
Insulin-Like Growth Factor Binding Protein 6
Insulin-Like Growth Factor Binding Protein 1
Cell Surface Receptors
Growth Hormone
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Carrier Proteins
Apoptosis
Peptides
Growth
Neoplasms

Keywords

  • IGF-binding proteins
  • IGF-receptors
  • IGFBP-proteases
  • Insulin-like growth factors

ASJC Scopus subject areas

  • Physiology

Cite this

The insulin-like growth factor system : IGFs, IGF-binding proteins and IGFBP-proteases. / Lelbach, A.; Müzes, G.; Fehér, J.

In: Acta Physiologica Hungarica, Vol. 92, No. 2, 2005, p. 97-107.

Research output: Contribution to journalArticle

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