The inhibitory effect of succinate on radiation-enhanced mitochondrial lipid peroxidation

Eva Ronai, Laszlo Tretter, Gyorgy Szabados, Istvan Horvath

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Abstract

The degree of mitochondrial ADP/Fe/NADPH-induced lipid peroxidation was increased up to the fourth day after 9·0 Gy whole body γirradiation. The lipid peroxidation inhibiting effect of succinate added to isolated mitochondria was diminished as a consequence of irradiation. The succinate, administered in vivo prior to irradiation, decreased the amount of malondialdehyde production and protected the succinate dehydrogenase enzyme against inactivation. The mean survival of succinate-pretreated animals was much longer than that of controls. The role of mitochondrial lipid peroxidation in the pathogenesis of radiation injury is discussed.

Original languageEnglish
Pages (from-to)611-617
Number of pages7
JournalInternational Journal of Radiation Biology
Volume51
Issue number4
DOIs
Publication statusPublished - Jan 1 1987

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Keywords

  • Lipid peroxidation
  • Mitochondria
  • Rat liver
  • Succinate

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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