The inhibitory effect of nitrite, a stable product of nitric oxide (NO) formation, on arginase

A. Hrabák, T. Bajor, Ágnes Temesi, G. Mészáros

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Abstract

Macrophages contain arginase and an inducible NO synthase, demonstrated by using L-arginine, the common substrate, for production of both nitric oxide and urea. Arginase was inhibited by nitrite, the stable end product of NO. This inhibition was non-competitive, and could not be explained by the reaction of nitrite with arginine, or by the irreversible covalent modification of arginase, or by the removal of Mn2+, a cofactor of arginase.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalFEBS letters
Volume390
Issue number2
DOIs
Publication statusPublished - Jul 22 1996

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Keywords

  • Arginase
  • Fluorescence
  • Inhibition
  • Macrophage
  • NO synthase
  • Nitrite

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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