The INHANCE consortium: Toward a better understanding of the causes and mechanisms of head and neck cancer

on behalf of the INHANCE consortium

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects.

Original languageEnglish
Pages (from-to)685-693
Number of pages9
JournalOral Diseases
Volume21
Issue number6
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Head and Neck Neoplasms
Epidemiology
Larynx
Mouth
Meta-Analysis
Hypopharynx
Oropharynx
Aptitude
Body Height
Mouth Neoplasms
Tobacco Use
Pharynx
Tobacco Products
Smoking
Alcohols
Research Personnel
Efficiency
Education
Research

Keywords

  • Epidemiology
  • Head and neck cancer

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology

Cite this

The INHANCE consortium : Toward a better understanding of the causes and mechanisms of head and neck cancer. / on behalf of the INHANCE consortium.

In: Oral Diseases, Vol. 21, No. 6, 01.09.2015, p. 685-693.

Research output: Contribution to journalArticle

on behalf of the INHANCE consortium. / The INHANCE consortium : Toward a better understanding of the causes and mechanisms of head and neck cancer. In: Oral Diseases. 2015 ; Vol. 21, No. 6. pp. 685-693.
@article{d703b894627149878a0f4efe52825bdb,
title = "The INHANCE consortium: Toward a better understanding of the causes and mechanisms of head and neck cancer",
abstract = "The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects.",
keywords = "Epidemiology, Head and neck cancer",
author = "{on behalf of the INHANCE consortium} and Winn, {D. M.} and Lee, {Y. C.} and M. Hashibe and P. Boffetta and Antonio Agudo and Wolfgang Ahrens and Vladimir Bencko and Simone Benhamou and Stefania Boccia and Cristina Bosetti and Paul Brennan and Hermann Brenner and Gabriella Cadoni and Xavier Castellsague and Chu Chen and David Conway and Curado, {Maria Paula} and Gypsyamber D'Souza and Maso, {Luigino Dal} and Daudt, {Alexander W.} and Ruyck, {Kim De} and Brenda Diergaarde and Jose Eluf-Neto and Eleonora Fabianova and Leticia Fernandez and Silvia Franceschi and Maura Gillison and Haddad, {Robert I.} and Richard Hayes and Claire Healy and Rolando Herrero and Jonathan Hofmann and Ivana Holc{\'a}tov{\'a} and Rayjean Hung and Karl Kelsey and Kristina Kjaerheim and Sergio Koifman and Vecchia, {Carlo La} and Martin Lacko and Pagona Lagiou and Philip Lazarus and Fabio Levi and Guojun Li and Jolanta Lissowska and Geoffrey Liu and Daniele Luce and Tatiana Macfarlane and Manoj Mahimkar and Dana Mates and P. Rudnai",
year = "2015",
month = "9",
day = "1",
doi = "10.1111/odi.12342",
language = "English",
volume = "21",
pages = "685--693",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - The INHANCE consortium

T2 - Toward a better understanding of the causes and mechanisms of head and neck cancer

AU - on behalf of the INHANCE consortium

AU - Winn, D. M.

AU - Lee, Y. C.

AU - Hashibe, M.

AU - Boffetta, P.

AU - Agudo, Antonio

AU - Ahrens, Wolfgang

AU - Bencko, Vladimir

AU - Benhamou, Simone

AU - Boccia, Stefania

AU - Bosetti, Cristina

AU - Brennan, Paul

AU - Brenner, Hermann

AU - Cadoni, Gabriella

AU - Castellsague, Xavier

AU - Chen, Chu

AU - Conway, David

AU - Curado, Maria Paula

AU - D'Souza, Gypsyamber

AU - Maso, Luigino Dal

AU - Daudt, Alexander W.

AU - Ruyck, Kim De

AU - Diergaarde, Brenda

AU - Eluf-Neto, Jose

AU - Fabianova, Eleonora

AU - Fernandez, Leticia

AU - Franceschi, Silvia

AU - Gillison, Maura

AU - Haddad, Robert I.

AU - Hayes, Richard

AU - Healy, Claire

AU - Herrero, Rolando

AU - Hofmann, Jonathan

AU - Holcátová, Ivana

AU - Hung, Rayjean

AU - Kelsey, Karl

AU - Kjaerheim, Kristina

AU - Koifman, Sergio

AU - Vecchia, Carlo La

AU - Lacko, Martin

AU - Lagiou, Pagona

AU - Lazarus, Philip

AU - Levi, Fabio

AU - Li, Guojun

AU - Lissowska, Jolanta

AU - Liu, Geoffrey

AU - Luce, Daniele

AU - Macfarlane, Tatiana

AU - Mahimkar, Manoj

AU - Mates, Dana

AU - Rudnai, P.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects.

AB - The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects.

KW - Epidemiology

KW - Head and neck cancer

UR - http://www.scopus.com/inward/record.url?scp=84938751008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938751008&partnerID=8YFLogxK

U2 - 10.1111/odi.12342

DO - 10.1111/odi.12342

M3 - Article

C2 - 25809224

AN - SCOPUS:84938751008

VL - 21

SP - 685

EP - 693

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 6

ER -